Women with polycystic ovary syndrome and primary infertility. Polycystic ovarian syndrome
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive letrozole with dexamethasone. In the first group, from the first day of menstruation, letrozole (Iran Hormone Company, Iran) wil
if not, the cycle will be canceled. Intervention 2: Control group: women in the study receive letrozole with a combined gonadotropin (oral-injectable). From the third day of menstruation, letrozole (I
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 39 Years
Inclusion criteria
Inclusion criteria: Women with a diagnosis of polycystic ovary syndrome and primary infertility Normal partner semen analysis ages between 18 and 39 years
Exclusion criteria
Exclusion criteria: Concomitant corticosteroid use ndocrine disorders (such as thyroid disorders, high prolactin due to prolactinoma) history of ovarian surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pregnancy outcome success rate in women with polycystic ovary syndrome and a history of infertility using dexamethasone. Timepoint: The patient will be referred for sonography on day 12 after menstruation. The patient will be asked to take steps to conceive. Finally, pregnancy was confirmed based on clinical level measurement by the presence of a gestational sac on sonography at the fourth week. Then, pregnancy and intrauterine insemination success rates in both groups will be compared. Method of measurement: Chemical pregnancy assessment by beta HCG check on days 12-16 after intervention and measurement of clinical pregnancy by the presence of a gestational sac on ultrasound at week 4.;Endometrial thickness in women with polycystic ovary syndrome and a history of infertility using dexamethasone. Timepoint: The patient will be referred for sonography on day 12 after menstruation. If the endometrial size is >7 and the dominant follicle is 17-25, a trigger will be given. The patient will be asked to take steps to conceive. If the endometrial and follicle conditions are not established, letrozole and dexamethasone will be continued for another 3-5 days, and another sonography will be performed. Method of measurement: Endometrial thickness in women with polycystic ovary syndrome and a history of infertility using dexamethasone by sonography.;Dominant follicle number, and pregnancy outcome success rate in women with polycystic ovary syndrome and a history of infertility using dexamethasone. Timepoint: The patient will be referred for sonography on day 12 after menstruation. If the endometrial size is >7 and the dominant follicle is 17-25, a trigger will be given. The patient will be asked to take steps to conceive. If the endometrial and follicle conditions are not established, letrozole and dexamethasone will be continued for another 3-5 days, and another sonography will be performed. Method of measurement: Dominant follicle number in women with polycystic ovary syndrom | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNeda Alimohammadi
Hamedan University of Medical Sciences
Outcome results
None listed