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Investigating the effectiveness of valacyclovir in gum disease

Investigating the effectiveness of systemic valacyclovir in preventing the progression of severe periodontitis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230519058230N1
Enrollment
40
Registered
2023-09-02
Start date
2023-05-20
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patienst with severe chronic periodontitis. Chronic periodontitis, generalized

Interventions

Intervention 1: Intervention group: scaling and root planning oral Hygine instructions full examinations, measurement of variables such as bleeding on probing and probe depth with Williams probe, and

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: patients with severe periodontitis Patients must be systemically healthy, Class I dental category Subjects with deep vertical periodontal lesions (>6 mm) showing no radiographic crestal alveolar lamina dura

Exclusion criteria

Exclusion criteria: Presence of any disease or medication that alters the immune system or interferes with healing ability Smokers (more than 10 cigarettes per day) Pregnant or nursing mothers because hormonal factors may influence the condition. Allergies or adverse reactions to valacyclovir Patients with renal impairment or reduced renal function

Design outcomes

Primary

MeasureTime frame
Pocket Depth. Timepoint: baseline- 3 and 6 months after the intervention. Method of measurement: Michigan O periodontal probe.;Bleeding on probing. Timepoint: baseline 3 and 6 months after the intervention. Method of measurement: michigan O periodontal probe.

Secondary

MeasureTime frame
Radiographic change in lamina dura bone. Timepoint: baseline and 6 months after intervention. Method of measurement: Panoramic radiography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanie shaygan majd

Mashhad University of Medical Sciences

hanie.shaygan@gmail.com+98 915 530 0436

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026