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Comparison Efficacy of platelet-rich fibrin membrane and melatonin on sensory recovery following mandibular fracture

Comparison Efficacy of platelet-rich fibrin membrane and melatonin on sensory recovery following mandibular fracture: a double-blind randomized trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230517058216N1
Enrollment
45
Registered
2023-07-27
Start date
2022-12-22
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lower lip and chin paresthesia due to mandibular fracture. Disturbances of skin sensation

Interventions

Intervention 1: Intervention group: In group 1, after exposing the fracture area, in cases of involvement of the lower alveolar canal, PRF prepared from the patient s blood is placed inside the bone a

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients whit no history of systemic diseases such as diabetes, kidney and liver problems Patients with no history of sensitivity to melatonin Patients who have informed consent to participate in the study Patients who have no history of previous mandibular surgery and nerve damage Patients with minimally displaced fractures that require open treatment of the mandible Patients with a level of GCS of 15, who are fully awake for examinations

Exclusion criteria

Exclusion criteria: Patients who have dissected nerve fibers at the fracture site Patients who have soft tissue injuries in the lower lip and chin area. Patients with mental retardation and psychotic disorders who do not cooperate for examinations Patients with blood and coagulation disorders

Design outcomes

Primary

MeasureTime frame
Improving the amount of lower lip paresthesia caused by mandibular fracture. Timepoint: One week, one month and three months. Method of measurement: Two-point discrimination, brush direction detection and self-expression (Visual Analogue Scale) tests.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Goodarzi

Yazd University of Medical Sciences

m.goodarzi.omfs@gmail.com+98 35 3312 2002

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026