Traumatic brain injury. Diffuse traumatic brain injury with loss of consciousness of unspecified duration, subsequent encounter
Conditions
Interventions
Intervention 1: The intervention group: in the period of 14 days, to meet the daily energy requirement of 1200 Kcal, they will be receive the designed ketogenic formulation in which the sugar content
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age =18 years Informed written consent of the patient or legal guardian of the patient Glasgow Coma Scale(GCS)<12
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding Hypoglycemia less than 70 Hypertriglyceridemia above 200 Hemoglobin concentration <80 g/L Patients diagnosed with sepsis Patients who are in shock and have indications for receiving vasopressors Dysfunction or severe liver and kidney failure Resistant lactic acidosis Hemodynamic or cardiopulmonary metabolic instability Severe infection Known disorders of fatty acid transport and oxidation Severe malnutrition Acute pancreatitis Patients with pyruvate decarboxylase deficiency porphyry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood beta-hydroxybutyrate assay. Timepoint: It is measured daily in the first 72 hours of the study, then on the 14th day of the end of the study. Method of measurement: blood test. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of days dependent on the mechanical ventilator, the assessment of Glasgow Outcome Scale scores (GOS), if it is not possible to record the GOS when the patient is discharged, the patient's report will be based on the improvement of the GCS, and finally the mortality rate will be considered as a secondary endpoint. Timepoint: The beginning and end of the study. Method of measurement: GCS and GOS calculation table. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShirin Shayanfar
Tehran University of Medical Sciences
Outcome results
None listed