Class III with maxilla deficiency and mandible prognathism. Anomalies of jaw-cranial base relationship
Conditions
Interventions
Intervention 1: Intervention group: Taking bromelain 200 mg powder inside the capsule three times a day for 8 days. Intervention 2: Control group: Taking the powder inside the placebo capsule three ti
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: Diagnosis of the Disease by an Orthodontist and Surgery by a Maxillofacial Surgeon Willingness to Cooperate and Sign the Informed Consent Form after being fully informed about the objectives and method of conducting the study Not taking supplements for at least one month before
Exclusion criteria
Exclusion criteria: Suffering from chronic diseases such as diabetes mellitus, kidney failure, liver disorder and cancer Suffering from other autoimmune and inflammatory diseases Suffering from hormonal disorders, thyroid disorders Alcohol consumption and hookah use Smoking and being exposed to secondhand smoke chronically Unwillingness to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of swelling before and after intervention. Timepoint: Days 1, 7, 30 after surgery will be compared with these measurements before surgery and immediately after surgery. Method of measurement: to evaluate the swelling of the total length of the considered lines in the anatomical areas of the face will be used.;2. Assessment of pain before and after intervention. Timepoint: Days 1, 7, 30 after surgery will be compared with these measurements before surgery and immediately after surgery. Method of measurement: Visual analogue scale will be used in this evaluation.;Evaluation of mouth opening before and after the intervention. Timepoint: Days 1, 7, 30 after surgery will be compared with these measurements before surgery and immediately after surgery. Method of measurement: with a ruler from the incisal edge of the centrals in the state of maximum mouth opening. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyedeh Maryam Omidkhoda
Mashhad University of Medical Sciences
Outcome results
None listed