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The effect of ephedrine and hydroxyethyl starch in the prevention of hypotension

Prophylactic administration of ephedrine and hydroxyethyl starch before spinal anesthesia to prevent hypotension in patients undergoing cesarean section

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230516058204N1
Enrollment
120
Registered
2023-08-05
Start date
2023-07-11
Completion date
Unknown
Last updated
2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Low blood pressure. Delivery by caesarean section, unspecified

Interventions

Intervention 1: The first intervention group: immediately after spinal anesthesia, they will receive 10 mg intravenous bolus of ephedrine. Intervention 2: The second intervention group: just before sp

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Having an ASA Class I, II term pregnancy (American Society of Anesthesiologists) Participants in the study should refer electively for caesarean section Consent to participate in the study Absence of any underlying disease Absence of contraindications for spinal anesthesia

Exclusion criteria

Exclusion criteria: Presence of one of the diseases associated with pregnancy, such as gestational hypertension, gestational diabetes, fetal problems, and bleeding in the third trimester of pregnancy. Allergy to ephedrine and hydroxyethyl starch or similar drugs BMI higher than 30 Gestational age less than 37 weeks Known hypertension Known heart or lung disease Known liver or kidney disease Addiction to amphetamine, cocaine and LSD

Design outcomes

Primary

MeasureTime frame
Blood pressure drop. Timepoint: During the operation. Method of measurement: By using the monitoring device.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Heidari

Shahre-kord University of Medical Sciences

dr_zahra_heidari@skums.ac.ir+98 38 3339 8456

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026