Thalassemia major disease. Beta thalassaemia
Conditions
Interventions
Intervention 1: Intervention group: People in the intervention group do 8 weeks of planned rehabilitation exercises.The exercise program includes aerobic and resistance exercises. The aerobic exercise
Sponsors
Bandare-abbas University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Thalassemia major patients who undergo regular blood transfusions and receive packed cells every month. Patients receiving iron chelator with regular blood transfusion such as desferal or deferiprone at the same time. Left ventricular ejection fraction equal to or more than 50% New York Heart Association (NYHA) functional class I, II, or III. Being in the age range of 18 to 40 years Having the desire and motivation to participate in the training program
Exclusion criteria
Exclusion criteria: Severe exercise intolerance uncontrolled arrhythmia, uncontrolled angina pectoris, severe kidney or lung disease, musculoskeletal or neuromuscular conditions that preclude exercise or exercise testing, and signs or symptoms of ischemia and abnormal hemodynamic responses during previous incremental exercise test, suffering from severe mental and psychiatric diseases, use of psychoactive drugs, uncontrolled blood pressure and diabetes, clinical evidence of other secondary causes of pulmonary hypertension including HIV infection, hepatitis virus infection, Collagen vascular diseases, cirrhosis, chronic obstructive airway diseases and acquired heart disease associated with pulmonary hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ferritin. Timepoint: Before the intervention and after the intervention. Method of measurement: Serum ferritin level by chemiluminescence method with Abbott Architect i1000SR Immunoassay System. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life. Timepoint: Before the intervention and after the intervention. Method of measurement: SF-36 questionnaire.;Mental health. Timepoint: Before the intervention and after the intervention. Method of measurement: SCL-90-R questionnaire.;HR Recovery. Timepoint: Before the intervention and after the intervention. Method of measurement: exercise test.;Exercise capacity. Timepoint: Before the intervention and after the intervention. Method of measurement: 6-minute walk test.;Cardiac function. Timepoint: Before the intervention and after the intervention. Method of measurement: Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public Contactzahra saadat
Bandare-abbas University of Medical Sciences
Outcome results
None listed