liver cirrhosis. Fibrosis and cirrhosis of liver
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will receive 30 grams of flaxseed powder daily for 12 weeks. Fresh flaxseed will be prepared and ground from Zarin giyahine store
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: All patients with liver cirrhosis whose cirrhosis has been confirmed by a specialist physician.
Exclusion criteria
Exclusion criteria: Those who have other extrahepatic diseases at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of liver cirrhosis according to Model for end stage liver disease score (MELD). Timepoint: Measurement of disease severity based on the MELD score before and 12 weeks after the start of flaxseed powder consumption. Method of measurement: Calculation of MELD using the formula and variables of bilirubin, creatinine and INR. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cirrhosis severity score based on child-Pugh. Timepoint: Measurement of mean cirrhosis severity based on child-Pugh score before and 12 weeks after flaxseed powder consumption. Method of measurement: child-Pugh calculation formula using the variables of bilirubin, albumin, INR (international normalized ratio), presence or absence of ascites and encephalopathy.;Level of serum total cholesterol. Timepoint: Measurement of mean level of serum total cholesterol before and 12 weeks after flaxseed powder consumption. Method of measurement: Auto Analyzer and Total Cholesterol Test Kit (Biorex).;Level of serum low density lipoprotein (LDL). Timepoint: Measurement of mean level of serum LDL before and 12 weeks after flaxseed powder consumption. Method of measurement: Auto Analyzer and LDL Test Kit (Biorex).;Level of serum high density lipoprotein (HDL). Timepoint: Measurement of mean level of HDL before and 12 weeks after flaxseed powder consumption. Method of measurement: Auto Analyzer and HDL Test Kit (Biorex).;Level of serum triglyceride (TG). Timepoint: Measurement of mean level of serum TG before and 12 weeks after flaxseed powder consumption. Method of measurement: Auto Analyzer and TG Test Kit (Biorex).;Level of serum fasting blood sugar (FBS). Timepoint: Measurement of mean level of FBS before and 12 weeks after flaxseed powder consumption. Method of measurement: Auto Analyzer and FBS Test Kit (Biorex).;Level of serum insulin. Timepoint: Measurement of mean level of serum insulin before and 12 weeks after flaxseed powder consumption. Method of measurement: Enzyme-linked immunosorbent double- antibody sandwich assay and insulin Test Kit (monobind).;Homeostatic Model Assessment (HOMA-IR ) index. Timepoint: Measurement of HOMA-IR before and 12 weeks after flaxseed powder consumption. Method of measurement: HOMA-IR calculation formula.;Quantitative insulin sensitivity check index (QUICKI). Timepoint: Measurement of QUICKI before and 12 weeks after flaxseed powder consump | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Haidari
Ahvaz University of Medical Sciences
Outcome results
None listed