Investigating the effect of pomegranate skin mouthwash on oral hygiene and bacterial colonization of oral and tracheal intubated patients admitted to the intensive care units(ICUs)

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230513058170N1

Enrollment

Registered

2023-06-20

Start date

2023-05-22

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Investigating the effect of pomegranate peel extract mouthwash on oral hygiene.

Interventions

Intervention 1: The intervention group-preparation of pomegranate peel extract from Adonisgol Daru Company-Tehran, has an international approval and certificate. Pomegranate peel extract with a concen

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Intubated patients admitted to the special care department of teaching hospitals in Zahedan - Patients with a tracheal tube and a level of consciousness of 3 to 7 on the GCS scale 2- Age 18 to 65 years 3- 24 hours have passed since the admission or hospitalization of the patient 4- Having natural teeth in the patient 5- Not having a history of allergy to pomegranate 6- Absence of a specific lesion in the mouth 7- The patient should not have radiotherapy experience 8- Willingness of the patient's legal guardian to continue participating in the study 9- Obtaining oral health evaluation checklist score less than 16.

Exclusion criteria

Exclusion criteria: - Airway damage during intubation 2- Pneumonia as an inpatient diagnosis 3- History of allergy to used mouthwash, asthma, allergic rhinitis and skin inflammation 4- Signs of sensitivity to mouthwash, such as redness, urticaria, and sores inside the mouth 5- Transfer of the patient from ICU or his death before the completion of the research

Design outcomes

Primary

Measure	Time frame
The bacterial colonization status of the tracheal tube of intubated patients. Timepoint: on the first day (before admission of patients) and on the fourth day in the ICU department. Method of measurement: Beck's measurement scale - oral mucosal plaque score - culture from Score obtained from the scale (MPS) = 2-4 a unacceptable MPS = 7-8 weak, the score received every day on the scale (BOAS). Number 5 no disorder, 6-10 mild disorder, 11-15 moderate disorder, 16-20 severe disorde?Cultivation on the first day (before admission of patients) and the fourth day in the ICU departmentmouth and tracheal tube.	—

Measure

Time frame

The bacterial colonization status of the tracheal tube of intubated patients. Timepoint: on the first day (before admission of patients) and on the fourth day in the ICU department. Method of measurement: Beck's measurement scale - oral mucosal plaque score - culture from Score obtained from the scale (MPS) = 2-4 a unacceptable MPS = 7-8 weak, the score received every day on the scale (BOAS). Number 5 no disorder, 6-10 mild disorder, 11-15 moderate disorder, 16-20 severe disorde?Cultivation on the first day (before admission of patients) and the fourth day in the ICU departmentmouth and tracheal tube.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh Saravani Pak

Zahedan University of Medical Sciences

msaravanipak@gmail.com+98 54 3328 9758

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026