Comparison of the efficacy of dual trigger HCG and GnRH agonist compared to HCG only in women with poor response undergoing with antagonist protocol

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230506058097N1

Enrollment

152

Registered

2023-06-06

Start date

2023-06-22

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Decreased ovarian reserve. Condition 2: Infertility. Condition 3: Poor response to ovarian stimulation. Female infertility associated with anovulation Female infertility

Interventions

Intervention 1: Intervention group: In this group, ovarian stimulation will be done with two GNRH agonist drugs and HCG drug. Buserlin agonist drug (Sinafect) manufactured by Sinagen company with a do

Eligibility

Sex/Gender

Female

Age

15 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women of reproductive age (from 15 to 45) with poor ovarian response who have at least two of the following criteria according to the Bologna criteria: age greater than or equal to 40 years, history of poor response with a maximum number of three oocytes obtained after stimulation or abnormal ovarian reserve confirmed by one of the two AFC test less than or equal to 7 or AMH less than or equal to 1.2 In the absence of criteria for old age or abnormal ovarian reserve, if a woman has a history of two weak responses after maximal ovarian stimulation Informed consent of clients to enter the research

Exclusion criteria

Exclusion criteria: Azospermia in the client's wife Women with polycystic ovary syndrome

Design outcomes

Primary

Measure	Time frame
The number of oocyte obtained. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: Observation (with microscope) and counting of eggs in the laboratory by an embryologist.;Chemical pregnancy. Timepoint: two weeks after embryo transfer. Method of measurement: Blood sampling, Measurement of BHCG Titer.;Clinical pregnancy. Timepoint: eight weeks after embryo transfer. Method of measurement: Ultrasound, visualization of the gestational sac and fetal heart.	—

Measure

Time frame

The number of oocyte obtained. Timepoint: 8 to 14 days after stimulation (according to ovarian response). Method of measurement: Observation (with microscope) and counting of eggs in the laboratory by an embryologist.;Chemical pregnancy. Timepoint: two weeks after embryo transfer. Method of measurement: Blood sampling, Measurement of BHCG Titer.;Clinical pregnancy. Timepoint: eight weeks after embryo transfer. Method of measurement: Ultrasound, visualization of the gestational sac and fetal heart.

—

Secondary

Measure	Time frame
Abortion. Timepoint: any time before 20 weeks of gestation. Method of measurement: Removal of pregnancy products before week 20.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarinaz Shahmoradi

Shahid Beheshti University of Medical Sciences

miss.shahmoradi@yahoo.com098 21 55082628

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026