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The effect of lactate on the inflammatory, motor, and cognitive profiles of people with type 3 diabetes

Comparison of six months of functional exercises above and below the lactate threshold on inflammatory, functional, and cognitive profile of patients with type 3 diabetes

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230502058055N2
Enrollment
150
Registered
2025-08-07
Start date
2025-09-21
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 3 Diabetes. Malnutrition-related diabetes mellitus with neurological complications

Interventions

Intervention 1: Intervention group 1: high-intensity functional exercises. Subjects of the functional group with an intensity higher than the lactate threshold (75-85% of the reserve heart rate, equiv

Sponsors

Shahrekord university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: Location of residence in the Shahr-e Kord, Farrokhshahr and Farsan Age of 60-80 years A score on the CANRISK Diabetes Questionnaire greater than 21 Suffering from cognitive impairment based on MMSE score less than 20 Obtaining physician clearance to begin a supervised exercise program Diagnosis of type 2 diabetes

Exclusion criteria

Exclusion criteria: Current medical condition for which exercise is contraindicated Regularly participated in resistance or aerobic exercise in the past 6 months Experience of a vascular event (e.g., stroke, myocardial infarction) Diagnosed mental illness or untreated depression and a score of 5 or less on the Geriatric Depression Scale Clinically significant peripheral neuropathy or severe musculoskeletal or joint disease Currently taking psychotropic medications

Design outcomes

Primary

MeasureTime frame
Processing speed score in the SDMT questionnaire. Timepoint: The evaluation will be done in the pre-test (before the start of the intervention) and the post-test (after the end of the intervention). Method of measurement: In order to evaluate the processing speed in the present research, the SDMT test is used to check the processing speed. The SDMT test consists of placing the number associated with a set of symbols in the 90 cells of a table, and the subject has 90 seconds to do this. The final score obtained from this test is considered as the processing speed score.;Inflammatory markers at serum level. Timepoint: The evaluation will be done in the pre-test (before the start of the intervention) and the post-test (after the end of the intervention). Method of measurement: At the serum level, these three items are measured as an inflammatory profile: 1- Neutrophil to Lymphocyte Ratio (NLR) 2- Platelet to Lymphocyte Ratio (PLR) 3- Systemic Immune Inflammation Index (SII).;Memory score in BVMT test. Timepoint: The evaluation will be done in the pre-test (before the start of the intervention) and the post-test (after the end of the intervention). Method of measurement: The BVMT test is related to visual memory, for this purpose, the subject must remember six geometric shapes on a white paper in a 10-second time and draw the shapes 3 times with 25-minute intervals. Putting each shape in its place and with the correct shape has 1 point respectively and the total of the test in each stage is 12 points. The average score of the 3 stages is considered as the memory score.;Learning score in CVLT test. Timepoint: The evaluation will be done in the pre-test (before the start of the intervention) and the post-test (after the end of the intervention). Method of measurement: The CVLT test is related to learning 16 words that are read by the test taker, and the test taker must try to write the words he has memorized five times with five minute intervals. Words generally consist o

Secondary

MeasureTime frame
Fasting blood sugar. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: Blood samples will be taken before and after 6 months of intervention to measure serum glucose.;Insulin. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: Blood samples will be taken before and after 6 months of intervention to measure serum insulin.;Glycated hemoglobin. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: Blood samples will be taken before and after 6 months of intervention to measure serum glycosylated hemoglobin.;Height. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: Height using a wall-mounted scale will be measured.;Weight. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: weight using a digital scale will be measured.;Body mass index. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: body mass index using the body mass index formula will be measured.;Aerobic endurance. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: In order to measure the ability to walk from a 6-minute walk test will be used.;Upper and lower body strength. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: upper body and lower body strength from handgrip tests and standing up and sitting 5 times.;Balance. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: balance using static and dynamic balance tests.;Speed. Timepoint: pre-test (before the intervention) and post-test (after the intervention). Method of measurement: speed using a 10 meter test.;Reaction speed. Timepoint: pre-test (be

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra raisifilabadi

Shahrekord university

z.raisi68.zr@gmail.com+98 913 590 8902

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026