Effect of weight bearing functional exercises and non-weight bearing quadriceps strengthening along with breathing exercises in people with knee osteoarthritis and obesity.

Effect of weight bearing functional exercises and non-weight bearing quadriceps strengthening along with breathing exercises on pain, functional activity, stress, lipid profile , cellular hypoxia and BDNF levels in people with knee osteoarthritis and obesity.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230427058007N1

Enrollment

Registered

2023-08-14

Start date

2023-01-01

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group 1: non weight bearing quardiceps strengthening exercises along with breathing exercises for 6 weeks. Each session will last 30–40?min. Participants will be provided

Eligibility

Sex/Gender

All

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: Are aged 40 to 60?years Both genders Have had knee pain for 3?months or more Report a minimum of 3 overall pain severity on 11-point numeric rating scale (NPRS) Demonstrate tibiofemoral osteophytes on x-ray

Exclusion criteria

Exclusion criteria: Lateral joint space narrowing greater than or equal to medial joint space narrowing on x-ray according to a radiographic atlas Knee surgery/joint injection in past 6?months or planned surgery in the next 9?months Current or past (4?weeks) oral corticosteroids use Systemic arthritic conditions Past knee fracture or malignancy Past hip/knee joint replacement/tibial osteotomy Unable to walk unaided

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: base line and after 6 weeks. Method of measurement: Numeric Pain Rating Scale.;Functional disability. Timepoint: base line and after 6 weeks. Method of measurement: The Western Ontario and McMaster universities Arthritis Index.;Brain Derived Neurotrophic levels levels. Timepoint: base line and after 6 weeks. Method of measurement: ELISA.;Oxygen saturation. Timepoint: base line and after 6 weeks. Method of measurement: Arterial blood gases.;Stress, Anxiety & Depression. Timepoint: base line and after 6 weeks. Method of measurement: Depression Anxiety and Stress Scale.;HDL and LDL. Timepoint: base line and after 6 weeks. Method of measurement: Lipid profile.	—

Measure

Time frame

Pain. Timepoint: base line and after 6 weeks. Method of measurement: Numeric Pain Rating Scale.;Functional disability. Timepoint: base line and after 6 weeks. Method of measurement: The Western Ontario and McMaster universities Arthritis Index.;Brain Derived Neurotrophic levels levels. Timepoint: base line and after 6 weeks. Method of measurement: ELISA.;Oxygen saturation. Timepoint: base line and after 6 weeks. Method of measurement: Arterial blood gases.;Stress, Anxiety & Depression. Timepoint: base line and after 6 weeks. Method of measurement: Depression Anxiety and Stress Scale.;HDL and LDL. Timepoint: base line and after 6 weeks. Method of measurement: Lipid profile.

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Countries

Pakistan

Contacts

Public ContactMuzna Munir

Riphah International University

muznafmh@gmail.com+92 334 4265125

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026