Effectiveness of topical treatment in patients with SRUS

Evaluating the response rate to local treatment in solitary rectal ulcer syndrome (SRUS) ulcerated type

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230425057990N1

Enrollment

Registered

2023-09-28

Start date

2022-12-22

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

solitory rectal ulcer syndrome. Ulcerative (chronic) rectosigmoiditis with rectal bleeding

Interventions

Intervention group: 20 patients under enema treatment. Enema is a combination of prednisolone 5 mg, sucralfate 1 gram and metronidazole 1 gram twice a day for about 3 months. Enema is done after defec

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with ulcerative type solitary rectal ulcer syndrome Patients over 18 years old

Exclusion criteria

Exclusion criteria: rectal prolapse psychological disease pelvic radiotherapy Distal colon surgery Bleeding ulcer

Design outcomes

Primary

Measure	Time frame
Bleeding. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Mucus secretion. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Difficult defecation. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Incomplete defecation. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.	—

Measure

Time frame

Bleeding. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Mucus secretion. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Difficult defecation. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.;Incomplete defecation. Timepoint: Before the intervention and 3 months after the intervention. Method of measurement: rectosigmoidscopy.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNajmeh Rad Goodarzi

Shahid Beheshti University of Medical Sciences

nradgoodarzi@gmail.com+98 21 2459 6000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026