Lichen planopilaris. Lichen planopilaris
Conditions
Interventions
Intervention 1: Intervention group: Methotrexate group with pioglitazone, test dose of MTX is given in the amount of 15 mg by injection. 1 week later, CBC, liver enzymes and kidney function will be ch
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: a disease that is resistant to treatment. It means that the treatment has been ineffective for at least 6 months. Newly diagnosed patients who have not yet received treatment. Patients who have been treated before and whose disease is still active. Patients who, for any reason, have discontinued any previous medication 1 month before entering the study and have not used any other medication at the time of the study. Patients between 18 and 50 years old
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding wbc<3000 platelet<100000 hemoglobin<9 Liver enzymes that are too normal for reference and active liver disease Positive tests for viral hepatitis Heart failure Type 1 diabetes Allergy to pioglitazone and methotrexate Bladder cancer Tissue edema
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lichen Planopilaris Activity Index. Timepoint: Months 0, 2, 4, and 6 after starting the drug. Method of measurement: Handyscope dermatoskope (FotoFinder System GmbH, Bad Brinbach, Germany. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFereshteh Sherafat
Esfahan University of Medical Sciences
Outcome results
None listed