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Comparison of effect of intranasal ketamine, intravenous morphine sulfate and intravenous ketorolac in acute renal colic

A comparative study of effect of intranasal ketamine, intravenous morphine sulfate and intravenous ketorolac in reducing pain in patients with acute renal colic

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230410057871N4
Enrollment
99
Registered
2024-10-09
Start date
2024-10-11
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute renal colic. Unspecified renal colic

Interventions

Intervention 1: First Intervention group: for these patients 1 mg/kg of ketamine is prescribed intranasally and 5 cc of normal saline is prescribed intravenously. Intervention 2: Second Intervention g

Sponsors

Khoram-Abad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients referred to the emergency department of Shohada Ashair Hospital who have the following conditions: Patients over 18 years old Presence of renal colic symptoms: pain in one or both flanks of the patient Diagnosis of kidney stones via CT scan or ultrasound

Exclusion criteria

Exclusion criteria: Pregnant women Patients addicted to opioids Patients with a history of allergy to morphine, ketamine, or ketorolac Patients with nasal obstruction Patients with systolic blood pressure higher than 180 or lower than 90 mmHg Patients with respiratory distress Patients with decreased level of consciousness Patients with a history of gastrointestinal bleeding Asthma patients Patients who have received medication in the past 48 hours Uncooperative patients

Design outcomes

Primary

MeasureTime frame
Pain score of patients in intranasal ketamine group. Timepoint: 15, 30, 45 and 60 minutes after the drug administration. Method of measurement: Visual Analogue Scale.;Pain score of patients in intravenous Morphine group. Timepoint: 15, 30, 45 and 60 minutes after the drug administration. Method of measurement: Visual Analogue Scale.;Pain score of patients in intravenous Ketrolac group. Timepoint: 15, 30, 45 and 60 minutes after the drug administration. Method of measurement: Visual Analogue Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactArian Karimi Rouzbahani

Khoram-Abad University of Medical Sciences

arian.karimi@sbmu.ac.ir+98 930 675 7977

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026