Investigating the effect of fluoxetine and online compassion-focused therapy in the treatment of post-chronic patients with post-traumatic stress disorder

The Comparison of the Effectiveness of Pharmacotherapy and online Compassion-Based Therapy in Reducing the Severity of Post Traumatic Symptoms, Increasing Post-Traumatic Growth, Improving Quality of life, and Studying Changes in Hippocampal and Amygdala Volume in Improved Patients with Coronavirus

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230408057849N1

Enrollment

Registered

2023-05-04

Start date

2021-08-22

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Traumatic Stress Disorder. Post-traumatic stress disorder (PTSD)

Interventions

Intervention 1: The first intervention group: Pharmacotherapy: Prozac brand name? fluoxetine drug from the serotonin reuptake inhibitors (SSRIs) category at a dose of 20 mg, 2 times a day, morning and

The first session: getting to know the group members with each other, explaining the group rules, explaining the symptoms of post-traumatic stress, talking about their problems, explaining how the min

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1- Being a resident of Shiraz city 2- having a positive PCR in Delta variant Corona virus 3- having a history of hospitalization and discharge.

Exclusion criteria

Exclusion criteria: Older participant Not living in Shiraz city Not having a history of hospitalization in the corona ward

Design outcomes

Primary

Measure	Time frame
The percentage of people whose questionnaire score was reported to be low. Timepoint: Measuring the severity of post-traumatic stress symptoms, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: Post-traumatic growth and development questionnaire, post-traumatic stress disorder questionnaire (PCL-5), World Health Organization quality of life questionnaire - short form, brain imaging to measure the Hippocampus and Amygdala.;The percentage of people whose questionnaire scores are high. Timepoint: Measurement of growth and development after the accident, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: Post-traumatic growth and development questionnaire.;The percentage of people whose questionnaire scores are reported to be high. Timepoint: Measuring the quality of life, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: World Health Organization quality of life questionnaire - short form.;Changes in the size of the Hippocampus and Amygdala. Timepoint: At the beginning of the study (before the interventions) and one year after the interventions. Method of measurement: Brain imaging to measure the hippocampus and amygdala.	—

Measure

Time frame

The percentage of people whose questionnaire score was reported to be low. Timepoint: Measuring the severity of post-traumatic stress symptoms, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: Post-traumatic growth and development questionnaire, post-traumatic stress disorder questionnaire (PCL-5), World Health Organization quality of life questionnaire - short form, brain imaging to measure the Hippocampus and Amygdala.;The percentage of people whose questionnaire scores are high. Timepoint: Measurement of growth and development after the accident, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: Post-traumatic growth and development questionnaire.;The percentage of people whose questionnaire scores are reported to be high. Timepoint: Measuring the quality of life, one week before the start of the intervention (pre-test) and 2 weeks after the intervention (post-test) and for the follow-up stage 3 months after the intervention. Method of measurement: World Health Organization quality of life questionnaire - short form.;Changes in the size of the Hippocampus and Amygdala. Timepoint: At the beginning of the study (before the interventions) and one year after the interventions. Method of measurement: Brain imaging to measure the hippocampus and amygdala.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Modaresifard

American Psychological Association

fatemehmodaresifard@gmail.com+98 71 3734 5881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026