Comparison of the effect of use of preoperative mexiletine tablets and placebo on reducing postoperative pain in patients undergoing abdominal surgery in Tehran Azad University hospitals in 2021-2023

Comparison of the effect of use of preoperative mexiletine tablets and placebo on reducing postoperative pain in patients undergoing abdominal surgery

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230405057824N1

Enrollment

Registered

2023-09-05

Start date

2022-08-23

Completion date

Unknown

Last updated

2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after abdominal surgery. Unspecified complication of procedure

Interventions

Intervention 1: One group received 600 mg mexilten tablets orally. The drug was administered two hours before the operation along with 50 cc of water. After the patients entered the operating room, th

Eligibility

Sex/Gender

All

Age

15 Years to 75 Years

Inclusion criteria

Inclusion criteria: Informed and written consent Elective surgery Age 15-75 Absence of drug and alcohol abuse

Exclusion criteria

Exclusion criteria: Loss of consciousness Hemodynamic disorder Abnormal intraoperative bleeding The duration of the operation is more than 4 hours

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: In recovery and at 6, 12, 24 hours after the operation, the amount. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
The amount of narcotic (pethidine) received after the operation. Timepoint: after surgery. Method of measurement: amount of drug used.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbolfazl Jadidi davoudabadi

Islamic Azad University

Abolfazl.jadidi2016@gmail.com+98 21 7719 0836

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026