Investigating the effect of the injection speed of the combination of neostigmine and atropine on the heart rate

Investigating the effect of the injection speed of the combination of neostigmine and atropine on the heart rate of patients under general anesthesia

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230405057822N1

Enrollment

Registered

2024-01-26

Start date

2021-03-21

Completion date

Unknown

Last updated

2024-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

the patients under going general anesthesia. Encounter for routine and ritual male circumcision

Interventions

Intervention 1: The first intervention group: reverse injection with a speed of 10 seconds including 3 mg of neostigmine and 1.5 mg of atropine to the first 23 patients. Intervention 2: The second int

Eligibility

Sex/Gender

All

Age

16 Years to 50 Years

Inclusion criteria

Inclusion criteria: Hemoglobin level above 14 g/dL Anesthesia class one ASA.PS

Exclusion criteria

Exclusion criteria: Patients with bleeding more than 10% blood volume Patients with a history of substance abuse and drug allergy and egg yolk allergy Having cardiac, vascular and respiratory disorders Receiving drugs that affect heart rate or central nervous system

Design outcomes

Primary

Measure	Time frame
Pulse rate. Timepoint: 10 seconds , 1minute , 3minutes. Method of measurement: monitoring device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Mirhosseini

Yazd University of Medical Sciences

mirhosseini@ssu.ac.ir+98 35 3623 8626

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026