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Synergistic comparison of the effectiveness of cognitive-behavioral therapy and cranial direct current stimulation therapy on the dorsal lateral prefrontal cortex on reducing cravings and clinical signs and improving neuropsychological functions in Stimulant substance abusers

Synergistic comparison of the effectiveness of cognitive-behavioral therapy (CBT) and cranial direct current stimulation therapy (tDCS) on the dorsal lateral prefrontal cortex (DLPFC) on reducing cravings and clinical signs and improving neuropsychological functions in amphetamin addicts .

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230318057753N1
Enrollment
40
Registered
2023-05-20
Start date
2023-05-05
Completion date
Unknown
Last updated
2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

addiction. Mental and behavioural disorders due to use of other stimulants, including caffeine

Interventions

Intervention 1: Intervention group: treatment only (CBT) In order to investigate the effectiveness of cognitive behavioral therap

Sponsors

Bojnourd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Primary diagnosis of amphetamine abuse based on clinical interview based on DSM-5 Age range 20-50 years He had at least middle school education Lack of diagnosis of any psychiatric disorder (except substance abuse) Not receiving any psychiatric medication for at least 6 months before entering the study Not receiving any other psychological intervention during the study Subjects' consent to participate in the research Not suffering from any specific physical disease Not suffering from neurological diseases (epilepsy, multiple sclerosis).

Exclusion criteria

Exclusion criteria: Having schizophrenia spectrum disorders and other psychotic disorders. Obsessive-compulsive disorder and related disorders. post-traumatic stress disorder and related disorders; Bipolar mood disorder and related disorders. Anxiety disorder caused by substances/drugs or caused by other medical conditions. Having a history of suicidal actions and thoughts. Having an injury in the head and neck area. history of consumption shorter than 6 months. History of implanting prosthesis in the head and neck area.

Design outcomes

Primary

MeasureTime frame
Craving for basic and induced amphetamines. Timepoint: Before the intervention, a pre-test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive-behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode-left cathode protocol and the third group received both treatments to check synergy. will do And the control group will not receive any intervention.After the implementation of the intervention, a post-test of all four groups will be conducted by implementing research questionnaires. Method of measurement: Questionnaire Amphetamine baseline craving questionnaire Video test to measure induced craving.;Clinical symptoms (anxiety and depression). Timepoint: Before the intervention, a pre-test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive-behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode-left cathode protocol and the third group received both treatments to check synergy. will do And the control group will not receive any intervention.After the implementation of the intervention, a post-test of all four groups will be conducted by implementing research questionnaires. Method of measurement: questionnaire Beck depression questionnaire Beck's anxiety.;Functions of neuropsychology (cognitive and behavioral inhibition). Timepoint: Before the intervention, a pre-test will be done from all four groups (three experimental groups and one control group) by implementing research questionnaires. Then, test group 1 received cognitive-behavioral therapy (CBT) and test group 2 received tDCS (DLPFC area) with the right anode-left cathode protocol and the third group receive

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Helmzadeh

Bojnourd University of Medical Sciences

Mahdi.helmzadeh@gmail.com+98 51 3867 6883

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026