Investigating the effect of caffeine on cognitive and motor responses

Effects of brushing with caffeinated toothpaste on cognitive and motor responses of the central nervous system: A pilot study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230318057752N2

Enrollment

Registered

2023-07-31

Start date

2023-08-23

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive and motor responses of the central nervous system.

Interventions

Intervention 1: Intervention group: The group receiving placebo capsule and toothbrush with 100mg caffeinated toothpaste for 2 minutes. Intervention 2: Intervention group: The group receiving placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy people with informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Any reaction or sensitivity to caffeine Addicted to drugs, alcohol and tobacco Consuming coffee and painkillers containing caffeine, nerve agents, tea and drinks that can affect the tests, from 48 hours before Cognitive disorders Mental disorders Cardiovascular diseases Neurological disorders Thyroid disorders Mouth or mucous membrane diseases

Design outcomes

Primary

Measure	Time frame
Serum caffeine level. Timepoint: 10, 30 and 60 minutes after receiving caffeine. Method of measurement: ELISA.;Selective attention capacity. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Selective processing speed. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Short-Term Memory. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Hand Eye Coordination. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.	—

Measure

Time frame

Serum caffeine level. Timepoint: 10, 30 and 60 minutes after receiving caffeine. Method of measurement: ELISA.;Selective attention capacity. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Selective processing speed. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Short-Term Memory. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.;Hand Eye Coordination. Timepoint: Before receiving caffeine, 10, 30 and 60 minutes after receiving caffeine. Method of measurement: Using computer tests.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKiarash Zare

Fasa University of Medical Sciences

kiarashzare1998@yahoo.com+98 71 5335 0994

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026