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The effect of ketamine along with gabapentin on complications of spinal anesthesia in caesarean section

Evaluation of the effect of ketamine with gabapentin on the severity of some complications of spinal anesthesia in cesarean section

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230316057741N1
Enrollment
120
Registered
2023-04-09
Start date
2023-05-20
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications after cesarean section. Single liveborn infant, delivered by cesarean

Interventions

Intervention 1: Intervention first group: Receive gabapentin (single oral dose, 300 mg) 30 minutes before surgery. Intervention 2: Intervention second group: Ketamine (intravenous dose of 0.25mg/kg a

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 34 Years

Inclusion criteria

Inclusion criteria: No emergency C/S surgery No emergency C/S surgery No emergency C/S surgery Type of surgical incision on the skin of Von Stilweber on the uterus, transverse incision on the lower uterine segment (kerr) Absence of underlying disease such as weak immune system, diabetes, high blood pressure, cardiopulmonary disease, blood disease, autoimmune disease, severe liver hepatitis, asthma, pancreatitis, or coagulation disorders. Singleton pregnancy Not taking special medicine Gestational age greater than or equal to 28 weeks Being in the low risk group based on the risk factors of PPH, including placenta previa, placental abruption, hypertension, HELLP syndrome, macrosomia, non-cephalic presentation, intrauterine infection or the use of assisted reproductive technology (ART). Mother's BMI based on pre-pregnancy weight less than 30 kg/m2 Natural plt counting

Exclusion criteria

Exclusion criteria: Any contraindications for spinal anesthesia Any contraindications to receiving ketamine or gabapentin Severe bleeding during C/S If any of the patients in the placebo group suffer from any of the side effects that cannot be tolerated by the patient, the patient will be treated for the side effects with the opinion of the relevant specialist, and the patient will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
Severity of postoperative nausea and vomiting. Timepoint: Their nausea and vomiting at intervals of 1, 2, 3, 4 and 6 hours. Method of measurement: A Visual Analogue Scale will be used to measure the severity of nausea and vomiting after the operation.;Severity of postoperative headache. Timepoint: Headache at intervals of 1, 6, 12 hours after the operation. Method of measurement: A Visual Analogue Scale will be used to measure the severity of headache.;Postoperative patient satisfaction score. Timepoint: Post-operation. Method of measurement: A Visual Analogue Scale will be used to measure the patient satisfaction.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Asadi Kalemeh

Yasouj University of Medical Sciences

zasadik66@gmail.com+98 74 3323 3257

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026