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Investigation of the Effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve block

Investigation of the Effect of topical application of amitriptyline and nortriptyline on irreversible pulpitis pain in teeth with failed pulpal anesthesia after a successful inferior alveolar nerve block

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230313057710N1
Enrollment
45
Registered
2023-04-27
Start date
2019-07-13
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis. Pulpitis

Interventions

Intervention 1: Intervention group 1: The diagnosis of irreversible pulpitis was confirmed by the heat and cold tests and presence of signs and symptoms of irreversible pulpitis such as severe long-la

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
10 Years to 68 Years

Inclusion criteria

Inclusion criteria: Patients requiring endodontic treatment of mandibular first molars showing the signs and symptoms of irreversible pulpitis and required treatment. Who had evidence of successful IAN block. Age 10-68 years

Exclusion criteria

Exclusion criteria: History of hypersensitivity to TCAs, lidocaine or epinephrine Lack of Systemic diseases (In according to self-report) Pregnancy and nursing mothers Patients who took systemic analgesics within 4-6 hours prior to dental visit, Patients with complete anesthesia and no pain.

Design outcomes

Primary

MeasureTime frame
[The outcome variable is Irreversible pulpitis. Timepoint: Pain will measure three times including: prior to the treatment onset, after the injection of anesthetic agent and initiation of access cavity preparation as the patient felt pain for the first time, and also after the application of medication. Method of measurement: McGill Visual Analogue Scale, Wong-Baker figure scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Khosravani

Esfahan University of Medical Sciences

z.khosravani@dnt.mui.ac.ir+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026