Simultaneous treatment of orthokine therapy and ozone therapy in knee arthrosis

Evaluation of the simultaneous effect of orthokine therapy and ozone therapy in the treatment of patients with knee osteoarthritis: A randomized controlled trails

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230311057677N1

Enrollment

120

Registered

2023-07-22

Start date

2023-08-23

Completion date

Unknown

Last updated

2023-07-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis. Arthrosis, unspecified

Interventions

Intervention 1: Intervention group 1: Patients receiving orthokine therapy with ozone. Artokine includes 4 injections of 2 ml of IL-1Ra on the first, seventh, fourteenth and twenty-first days of treat

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with knee osteoarthritis with grades 2 and 3 in the Kellgren and Lawrence criteria

Exclusion criteria

Exclusion criteria: The presence of coagulation disorders Taking anticoagulants Infection at the injection site

Design outcomes

Primary

Measure	Time frame
Pain Intensity. Timepoint: Before intervention and 1-3 -6 months after the start of the intervention. Method of measurement: WOMAC (Western Ontario and McMaster University) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Hajrezaei

Ghoum University of Medical Sciences

z.rezaei5054@gmail.com+98 25 3285 2720

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026