Investigating the effect of Tranexamic acid in bleeding after caesarean section.

Investigating the effectiveness of the simultaneous use of Tranexamic acid and Oxytocin compared to the use of Oxytocin alone on the amount of bleeding after caesarean section .

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230307057644N2

Enrollment

140

Registered

2024-07-30

Start date

2023-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum hemorrhage. Postpartum hemorrhage

Interventions

Intervention 1: Control group: In the third stage of labor, only 30 units of Oxytocin are injected intramuscular (IM) by the nurse to 82 patients included in the study. Intervention 2: Intervention gr

in addition to 30 units of Oxytocin (intramuscular), 1 g of Tranexamic acid is injected intravenously (IV) to 81 patients.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Patients who referred to Afzalipour Kerman Hospital for elective or emergency caesarean section in 2023.

Exclusion criteria

Exclusion criteria: Patients with placenta Accreta and previa. Patients who have a history of uterine atony. Patients who have a history of uterine rupture. Patients who have a history of coagulation disorders. Patients with chorioamnionitis. Patients with hematologic disorders. Patients who have a history of myomectomy.

Design outcomes

Primary

Measure	Time frame
The amount of bleeding. Timepoint: Measuring the patient's hemoglobin before delivery and 6 hour after delivery. Method of measurement: Blood test for complete blood cells( CBC).	—

Secondary

Measure	Time frame
Requirement to blood transfusions (Packed cell) and blood products (Platelets and Fresh Frozen Plasma). Timepoint: During delivery, 6 hours after delivery and one turn within the first 24 hours after delivery. Method of measurement: Due to the volume of bleeding during delivery and the rate of decrease in hemoglobin in the blood test.;Uterine atony. Timepoint: It is checked every 15 minutes in the first hour after delivery, every 30 minutes in the second hour after delivery, and then during the first 2 to 24 hours after delivery. Method of measurement: Frequent examination of the uterine fundus.;The need to use uterotonic drugs such as Methergin, Misoprostol, Factor 7, Prostaglandin. Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, which medicine was used based on the opinion of the obstetrician and gynecologist.;The need to use a Bakri Balloon. Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, a Bakri Balloon is inserted based on the opinion of the obstetrician and gynecologist.;The need for surgery to remove the uterus (hysterectomy). Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, hysterectomy is performed based on the opinion of the obstetrician and gynecologist.	—

Measure

Time frame

Requirement to blood transfusions (Packed cell) and blood products (Platelets and Fresh Frozen Plasma). Timepoint: During delivery, 6 hours after delivery and one turn within the first 24 hours after delivery. Method of measurement: Due to the volume of bleeding during delivery and the rate of decrease in hemoglobin in the blood test.;Uterine atony. Timepoint: It is checked every 15 minutes in the first hour after delivery, every 30 minutes in the second hour after delivery, and then during the first 2 to 24 hours after delivery. Method of measurement: Frequent examination of the uterine fundus.;The need to use uterotonic drugs such as Methergin, Misoprostol, Factor 7, Prostaglandin. Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, which medicine was used based on the opinion of the obstetrician and gynecologist.;The need to use a Bakri Balloon. Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, a Bakri Balloon is inserted based on the opinion of the obstetrician and gynecologist.;The need for surgery to remove the uterus (hysterectomy). Timepoint: During delivery and the first 24 hours after delivery. Method of measurement: According to the amount of bleeding, hysterectomy is performed based on the opinion of the obstetrician and gynecologist.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGhazal Mansouri

Kerman University of Medical Sciences

mansori@kmu.ac.ir+98 34 3132 5700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026