Sarcopenia.
Conditions
Interventions
Intervention 1: Intervention group: It will contain subgroups of an equal number of males and females. This group will receive 10 bouts of WBV with frequency progressively increasing from 15 to 40 Hz
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Elderly aged 60 years and above Participants who meet sarcopenia diagnostic criteria based on the EWGSOP2 algorithm for case-finding and diagnosis with Skeletal Muscle Index (SMI) <7.0 kg/m2 and <5.5 kg/m2 for males and females, respectively Negative Romberg's sign Participants who are willing to comply with the study protocol and give informed consent in writing
Exclusion criteria
Exclusion criteria: Participants who meet “severe” sarcopenia diagnostic criteria based on the EWGSOP2 algorithm for case-finding and diagnosis with a score of =8 on Short Physical Performance Battery (SPPB) Presence of any neuromuscular, autoimmune, or infectious diseases Participants with Total Hip Replacement, Total Knee Replacement and any other lower limb implants Participants unable to flex the knee joints to 90° or having pain in their knees or ankles due to any problem such as arthritic changes Participants with any critical cognitive (Mini–Mental State Examination, MMSE score?<?23) or physical dysfunctions that may interfere with the test or training procedures Participants with cardiovascular and/or pulmonary diseases, which can get aggravated after exercise Participants who are taking drugs that can affect the neuromuscular system Participants who are osteoporotic with T-score < -2.5 on DEXA at the lumbar spine/ femoral neck/distal third of the radius
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fall risk. Timepoint: before intervention, after intervention and 8 weeks post termination of intervention. Method of measurement: Falls Efficacy Scale-International which is a short, easy to administer tool that measures level of concern about falling during social and physical activities inside and outside the home whether or not the person usually does the activity. The level of concern is measured on a four-point Likert scale (1=not at all concerned to 4=very concerned) with score of 16 denoting no concern about falling while score of 64 denotes severe concern about falling.;Skeletal Muscle Index (SMI). Timepoint: before intervention, after intervention and 8 weeks post termination of intervention. Method of measurement: Dual-energy X-ray absorptiometry (DEXA) will be carried out for each participant by the same technician. All assessments will be performed at the same time in the day around 10 a.m. to 12 noon.;Muscle strength. Timepoint: before intervention, after intervention and 8 weeks post termination of intervention. Method of measurement: Dynamometer for the hand grip strength and knee strength will be used. For measuring hand grip strength, participant will be asked to squeeze the handle of dynamometer as strongly as possible while three readings will be noted in kilograms from the alternate hand to relax the other hand. After three trials, the highest value of the 3 repetitions will be considered for each hand separately. For measuring maximal isometric strength of knee extensors, the participants will be instructed to sit with their hips and knees at 90 degrees flexion, legs perpendicular to the floor and the feet not touching the ground. The dynamometer will be placed just proximal to the ankle on the front leg. A high density foam pad may be placed between the dynamometer's force pad and the subjects' leg for comfort and to protect subjects' skin. During testing, the subjects will be instructed to contract maximally and to sustain the maximal volunt | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: before intervention, after intervention and 8 weeks post termination of intervention. Method of measurement: SarQoL questionnaire which is a self-administered questionnaire comprising of 55 items and 22 questions and is organized into 7 domains of health related quality of life (QOL) including Physical and Mental Health, Locomotion, Body composition, Functionality, Activities of daily living, Leisure activities and Fears. Each domain is scored from 0 (worst QOL) to 100 (best QOL) and overall score is calculated.;Inflammatory markers. Timepoint: before intervention, after intervention and 8 weeks post termination of intervention. Method of measurement: Plasma levels will be assessed for each participant in the pathologic lab through blood sample obtained from antecubital vein between 8 a.m. to 10 a.m. | — |
Countries
Pakistan
Contacts
Public ContactShafaq Altaf
Tehran University of Medical Sciences
Outcome results
None listed