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The effect of misoprostol, and metrogen with oxytocin in reducing of postpartum hemorrhage

Investigating the incidence of postpartum hemorrhage in high-risk pregnant women who underwent cesarean section after the prophylactic administration of misoprostol, metrogen, and oxytocin compared to oxytocin alone

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230227057554N1
Enrollment
240
Registered
2023-03-18
Start date
2023-05-20
Completion date
Unknown
Last updated
2023-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum hemorrhage. Postpartum hemorrhage

Interventions

Intervention 1: Intervention group: In these women, the intravenous infusion of 40 units of oxytocin (produced by Aburaihan Pharmaceutical Manufacturing) in 1 liter of Ringer's serum at a rate of 10 c

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Singleton term pregnant women who have an indication for termination of pregnancy (37-40 weeks). Have an indication for an elective cesarean section. At least one risk factor for postpartum bleeding (such as polyhydramnios, multiparity, having a history of postpartum bleeding, macrosomia, and anemia).

Exclusion criteria

Exclusion criteria: Emergency cesarean section Abnormal fetal heartbeat Vaginal bleeding Person with unexpected bleeding during the surgery Severe anemia (hemoglobin less than 8 mg/dL) before surgery Advanced underlying diseases History of coagulation disorders Low-lying placenta, decolman or accreta previa Reaction history to the drugs

Design outcomes

Primary

MeasureTime frame
Incidence of postpartum hemorrhage. Timepoint: Once, six hours after the caesarean section. Method of measurement: Number of pads used in the first six hours after the caesarean section.

Secondary

MeasureTime frame
Hemoglobin and hematocrit concentration. Timepoint: Once, six hours after the cesarean section. Method of measurement: Complete blood count.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahboobeh Shirazi

Tehran University of Medical Sciences

mahboobehshirazi4@gmail.com+98 21 4216 0852

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026