Evaluation the effect of prolonging the duration of administration of Colistin infusion on the Colistin-induced nephrotoxicity

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230225057533N1

Enrollment

Registered

2023-05-27

Start date

2023-03-04

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nephrotoxicity.

Interventions

Intervention 1: Intervention group: Infusion of colistin 1million unit in 2 hours. Intervention 2: Control group: Control group: Clostin drug infusion for 20 minutes.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: At least 18 years old Infection with Multidrug resistance organism Sputum culture be positive with Acinetobacter baumannii , Klebsiella pneumoniae

Exclusion criteria

Exclusion criteria: Discontinue treatment with colistin Receiving other nephrotoxic drugs at the same time Oliguria (urine output less than 500 cc in 24 hours) Hypotension due to a reason other than sepsis (embolism, MI, hypovolemic shock), receiving NSAIDs Receive albumin receiving contrast agents Estimated glomerular filtration rate (eGFR) less than 5 mL/min/1.73 m2

Design outcomes

Primary

Measure	Time frame
Level ofCreatinine and BUN. Timepoint: Daily. Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Somayeh Shabib

Arak University of Medical Sciences

shabib333@gmail.com009833838392

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026