diabetes. Type 2 diabetes mellitus
Conditions
Interventions
Intervention 1: Intervention group 1: will receive only the interventions of 8 weeks of aerobic training (weeks one to four will be 3 sessions and weeks four to eight will be 4 sessions per week). In
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
30 Years to 55 Years
Inclusion criteria
Inclusion criteria: Minimum age 30 and maximum 55 years Excessive hyperglycemia (HbA1c > 10%) Diabetic microvascular complications Diabetic neuropathy Impaired liver function (plasma aminotransferase and/or g-glutamyltransferase level above the upper limit of normal for age and sex) Renal dysfunction (serum creatinine level higher than normal for age and sex) Severe anemia Uncontrolled blood pressure (blood pressure > 100/170 mm Hg) Obvious heart-related symptoms or history of cerebrovascular events Patients with cardiovascular disease (class I-IV congestive heart failure or history of myocardial infarction) Patients on insulin therapy will not be eligible Active patients who reported more than 1 exercise per week
Exclusion criteria
Exclusion criteria: Patients treated with insulin Having no history of cardiovascular diseases and respiratory problems Patients who do sports.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of women with type 2 diabetes. Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: Blood sugar test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Insulin sensitivity. Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: ?? ??????? ?? ???? QUICKI ????? ??? ?? ???? ??????QUICKI = 1/(log insulin [AIU/mL] + log glucose [mg/dL]) ??????? ????? ??. ???? QUICKI ????? ???? ????? ?????? ?? ?? ??????? ???? ?? ???? ?? ???? QUICKI ???? ???? ????? ?????? ?? ??????? ???? ???.;Determination of serum glucose concentration. Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: Fasting glucose concentration will be measured using Iran's Pars test kit and calorimeter (glucose oxidase) method.;Determination of BAX and BCL2 serum levels. Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: To investigate the concentration of Bax and Bcl2, it will be done using the ELISA kit of Podgin Teb Company.;Measurement of superoxide dismutase (SOD). Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: The amount of superoxide dismutase activity is indirectly measured using the calorimetric method based on the ability of SOD to inhibit pyrogallol autoxidation.;Measurement of Glutathione Peroxidase (GPX). Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: Glutathione peroxidase assay is based on the ability of glutathione peroxidase to oxidize glutathione (GSH) to oxidized glutathione (GSSH). (GSSH) is part of the reactions that reduce cumene hydroperoxide. Glutathione reductase then converts GSSH to GSH by consuming nicotinamide dinucleotide phosphate (NADPH). The reduction of NADPH measured at 340 nm is an indicator of glutathione peroxidase activity.;Determination of malondialdehyde (MDA). Timepoint: Before the intervention, 8 weeks after the intervention. Method of measurement: It will be determined based on the reaction with thiobarbituric acid (TBA) and using a spectrophotometric method at a wavelength of 532 nm.;Measurement of total antioxidant capa | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKeyvan Khoramipour
Kerman University of Medical Sciences
Outcome results
None listed