Investigating the effect of photodynamic therapy in reducing caries in removable orthodontics

Evaluation of antimicrobial photodynamic therapy effects of orthodontic resin acrylic containing Curcumin-nisin poly-lactic acid nanoparticles (CurNisNp): A randomized, double-blind case-control clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230223057507N1

Enrollment

Registered

2023-06-04

Start date

2023-04-04

Completion date

Unknown

Last updated

2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

orthodontics.

Interventions

Intervention 1: The device used in the intervention group is a removable appliance made of acrylic methacrylate (Sigma-Aldrich) containing 5% curcumin-nisin poly-lactic acid nanoparticles. The curcumi

Eligibility

Sex/Gender

All

Age

7 Years to 15 Years

Inclusion criteria

Inclusion criteria: Has at least 20 permanent teeth Treatment plan with movable orthodontic appliance (acrylic).

Exclusion criteria

Exclusion criteria: Extensive tooth fillings Removable denture Underlying diseases Periodontal diseases Tooth loss due to extensive caries Use of antibiotics in less than 1 month Lack of Streptococcus mutans in the screening phase (Base line)

Design outcomes

Primary

Measure	Time frame
Changing the population of effective bacteria in dental caries. Timepoint: Measuring the population of Streptococcus mutans at the beginning of the study (before the start of the intervention) and 30, 60, 90, 120, 150 and 180 days after using the removable acrylic resin appliance. Method of measurement: Counting of bacterial population via serial dilution.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Bahador

Tehran University of Medical Sciences

ab.bahador@gmail.com+98 21 8895 5810

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026