Female infertility with thin endometrium. Female infertility of uterine origin
Conditions
Interventions
Intervention group: patients will be received three injections of Umbilical cord-derived Mesenchymal Stem Cells and their secretome..
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 44 Years
Inclusion criteria
Inclusion criteria: Infertile women with thin endometrium patient with thin endometrium for whom drugs and other treatments were ineffective Endometrial thickness less than 7 mm Embryo transfer is cancelled because of thin endometrium Age between 20 and 44 years HBsAg negative, HCV negative, HIV negative, CMV negative
Exclusion criteria
Exclusion criteria: Abnormal karyotype Contraindications to hormone replacement therapy Systemic diseases such as hypertension, diabetes Other uterine diseases including uterine malformations, large myoma, endometrial tuberculosis, endometriosis Autoimmune diseases such as rheumatoid arthritis, lupus Unable to adhere to the follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrium thickness. Timepoint: Before the intervention and 1, 2 and 3 months after the first intervention. Method of measurement: Vaginal sonography. | — |
Secondary
| Measure | Time frame |
|---|---|
| The effect of cell therapy on fertility rate of patients. Timepoint: 15 days after embryo transfer. Method of measurement: Using sonography and serum beta-human chorionic gonadotropin (ß-hCG) level assessment by enzyme-linked immunosorbent assay (ELISA) or chemi luminescence. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSaeedeh Torabi Goudarzi
Tehran University of Medical Sciences
Outcome results
None listed