Investigation the effects of Arctium Lappa root powder in women with polycystic ovary syndrome

Investigation the effects of Arctium Lappa root powder on some markers of oxidative stress and inflammation in women with polycystic ovary syndrome: a randomized double blind clinical trial study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230222057492N1

Enrollment

Registered

2023-03-29

Start date

2023-04-04

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: One capsule Arctium Lappa root powder (460 mg) per day for 12 weeks. Intervention 2: Control group: One capsule placebo starch (460 mg) per day for 12 weeks.

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Women in the age range of 18-45 years Confirmation of PCOS by a specialist doctor, based on Rotterdam criteria Patient satisfaction to enter the study Patients who do not intend to become pregnant because the profile of therapeutic drugs for people who intend to become pregnant is different from those who do not intend to become pregnant

Exclusion criteria

Exclusion criteria: Smoking consumption of anticoagulant drugs and antioxidant and anti-inflammatory supplements for 3 months before the study. Pregnancy Breastfeeding Diabetes Thyroid disorders Hyperprolactinemia

Design outcomes

Primary

Measure	Time frame
Superoxide dismutase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Catalase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Glutathione peroxidase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Reduced glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Oxidized glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;The ratio of reduced glutathione to oxidized glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total antioxidant capacity. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Total oxidant status. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Oxidative stress index. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Malondialdehyde. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Ratio of malondialdehyde to total antioxidant capacity. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total antioxidant gap. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total Thiol. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;C-reactive protein. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Turbidimetry.;The ratio of C-reactive protein to albumin. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;The ratio of blood urea nitrogen to albumin. T	—

Measure

Time frame

Superoxide dismutase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Catalase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Glutathione peroxidase. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Reduced glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Oxidized glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;The ratio of reduced glutathione to oxidized glutathione. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total antioxidant capacity. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Total oxidant status. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Oxidative stress index. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Malondialdehyde. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;Ratio of malondialdehyde to total antioxidant capacity. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total antioxidant gap. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;Total Thiol. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Colorimetric.;C-reactive protein. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Turbidimetry.;The ratio of C-reactive protein to albumin. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.;The ratio of blood urea nitrogen to albumin. T

—

Secondary

Measure	Time frame
Body mass index. Timepoint: Before and 12 weeks after the start of the intervention. Method of measurement: Formula.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Taheri

Arak University of Medical Sciences

haniehtaheri1997@yahoo.com+98 86 3417 3645

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026