Evaluation of the effects of fasting diet in patients with rheumatoid arthritis

The evaluation of the effects of intermittent fasting diet on clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with rheumatoid arthritis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230217057441N1

Enrollment

Registered

2023-03-05

Start date

2023-03-06

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis. Rheumatoid arthritis with rheumatoid factor

Interventions

Intervention 1: Intervention group: The people of the intervention group have an intermittent fasting diet of the type (16:8) in which people are only allowed to receive water and non-energy drinks, t

Eligibility

Sex/Gender

Female

Age

50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Women Body mass index 25-35 kg/m2 Age range between 50 and 70 years Menopause Diagnosed with rheumatoid arthritis by a rheumatologist for more than 6 months Moderate to low rheumatoid arthritis disease activity (i.e. disease activity score <5.1) Following a stable drug regimen for 3 months before the intervention Not receiving non-steroidal anti-inflammatory drugs (NSAIDs) Willingness to cooperate

Exclusion criteria

Exclusion criteria: Consumption of alcohol Suffering from other autoimmune diseases, kidney diseases, pancreatitis, gallstones, cancer Pregnancy and breastfeeding Following a special diet in the last three months Changing the medication regimen from 3 months

Design outcomes

Primary

Measure	Time frame
In this study, HAQ score is considered as the primary outcome. Timepoint: Investigating the effects of clinical symptoms, inflammation and oxidative stress at the beginning of the study (before the start of the intervention) and 8 weeks after the start of the intermittent fasting diet in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire for health assessment-disability index: In order to evaluate the performance of patients, it will be completed by the project manager at the beginning and end of the study, and by asking the patients.	—

Measure

Time frame

In this study, HAQ score is considered as the primary outcome. Timepoint: Investigating the effects of clinical symptoms, inflammation and oxidative stress at the beginning of the study (before the start of the intervention) and 8 weeks after the start of the intermittent fasting diet in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire for health assessment-disability index: In order to evaluate the performance of patients, it will be completed by the project manager at the beginning and end of the study, and by asking the patients.

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Secondary

Measure	Time frame
The level of total oxidant and antioxidant capacity. Timepoint: The effect of intermittent fasting diet on the level of total oxidant and antioxidant capacity at the beginning of the study (before the start of the intervention) and 8 weeks after the start in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Calorimetry kit: It will be measured from colorimetric methods with microplate spectrophotometer to measure TAC and TOC at the beginning and end of the study.;Symptoms of rheumatoid arthritis. Timepoint: The effect of intermittent fasting on the symptoms of rheumatoid arthritis at the beginning of the study (before the intervention) and 8 weeks after the intervention in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire to evaluate the degree of swelling and tenderness of joints in rheumatoid arthritis patients, questionnaire of perceived visual pain of the patient, questionnaire of health-disability index, questionnaire to evaluate the level of disease activity by the patient, questionnaire to evaluate the level of disease activity by the researcher, questionnaire to evaluate morning stiffness.;Inflammation. Timepoint: The effect of intermittent fasting diet on inflammation at the beginning of the study (before the start of the intervention) and 8 weeks after the start in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Erythrocyte sedimentation rate or ESR and C-reactive protein or CRP.	—

Measure

Time frame

The level of total oxidant and antioxidant capacity. Timepoint: The effect of intermittent fasting diet on the level of total oxidant and antioxidant capacity at the beginning of the study (before the start of the intervention) and 8 weeks after the start in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Calorimetry kit: It will be measured from colorimetric methods with microplate spectrophotometer to measure TAC and TOC at the beginning and end of the study.;Symptoms of rheumatoid arthritis. Timepoint: The effect of intermittent fasting on the symptoms of rheumatoid arthritis at the beginning of the study (before the intervention) and 8 weeks after the intervention in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Questionnaire to evaluate the degree of swelling and tenderness of joints in rheumatoid arthritis patients, questionnaire of perceived visual pain of the patient, questionnaire of health-disability index, questionnaire to evaluate the level of disease activity by the patient, questionnaire to evaluate the level of disease activity by the researcher, questionnaire to evaluate morning stiffness.;Inflammation. Timepoint: The effect of intermittent fasting diet on inflammation at the beginning of the study (before the start of the intervention) and 8 weeks after the start in postmenopausal, overweight and obese women with rheumatoid arthritis. Method of measurement: Erythrocyte sedimentation rate or ESR and C-reactive protein or CRP.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactKurosh Djafarian

Tehran University of Medical Sciences

info_snsd@tums.ac.ir+98 21 8895 5975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 6, 2026