The effectiveness of dexmedetomidine on pain relief after unilateral total knee arthroplasty

A clinical trial to compare the effectiveness of bupivacaine along with dexmedetomidine with bupivacaine on adductor canal block after unilateral total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230215057432N1

Enrollment

Registered

2023-02-21

Start date

2023-03-21

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unilateral total knee arthroplasty. Presence of orthopaedic joint implants

Interventions

Intervention 1: Intervention group: The intervention group will receive 15 mg bupivacaine 0.5% (Darou Darman Pars, Iran) along with 1 mg/kg dexmedetomidine (Darou Darman Arang, Iran) to adductor canal

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients candidate for unilateral total knee arthroplasty Age over 18 years

Exclusion criteria

Exclusion criteria: Having a contraindication for adductor canal block Having diabetes mellitus Having local anesthetics allergies Bradycardia Long-term use of analgesics Having liver failure Having renal failure

Design outcomes

Primary

Measure	Time frame
The rate of pain. Timepoint: 1, 3, 6, 12, 18 and 24 hours after intervention. Method of measurement: Visual analogue scale (VAS).	—

Secondary

Measure	Time frame
The rate of pain reliever consumption. Timepoint: 24 hours after intervention. Method of measurement: Type and amount of pain reliever consumed by the patient.;Prescribing the first pain reliever after surgery. Timepoint: After intervention. Method of measurement: Based on minutes after surgery.;100-step walking test time. Timepoint: Before, one and two days after intervention. Method of measurement: Based on minutes.	—

Measure

Time frame

The rate of pain reliever consumption. Timepoint: 24 hours after intervention. Method of measurement: Type and amount of pain reliever consumed by the patient.;Prescribing the first pain reliever after surgery. Timepoint: After intervention. Method of measurement: Based on minutes after surgery.;100-step walking test time. Timepoint: Before, one and two days after intervention. Method of measurement: Based on minutes.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sharafi

Mashhad University of Medical Sciences

Sharafim991@mums.ac.ir+98 51 3854 3031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026