Carbon dioxide laser in dentin hypersensitivety

Clinical efficacy of ultra-pulsed CO2 laser with and without topical fluoride gel for dentin hypersensitivity: a randomized split-mouth clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230213057400N2

Enrollment

Registered

2026-05-12

Start date

2015-11-17

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin hypersensitivity.

Interventions

Intervention 1: Intervention group: Intervention group 1: Active ultra pulsed carbon dioxide laser irradiation is applied on the buccal surface of hypersensitive teeth using a device with wavelength o

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: =1 hypersensitive teeth per quadrant age >18

Exclusion criteria

Exclusion criteria: pregnancy lactation systemic conditions influencing hypersensitivity (e.g., chronic gastroesophageal reflux) desensitizing therapy within the past 6 months long-term analgesic/anti-inflammatory use recent scaling or bleaching (=6 months) use of desensitizing toothpastes/mouth rinses orthodontic appliances or removable partial dentures dental/structural pathology explaining pain (e.g., caries, extensive restorations, cracks, pulpal disease) Age >18

Design outcomes

Primary

Measure	Time frame
Pain intensity induced by cold stimulus in teeth with dentin hypersensitivity. Timepoint: At baseline before intervention; ten minutes after initial treatment; two days after treatment ten minutes after gel application; four days after treatment ten minutes after gel application; two weeks after intervention; four weeks after intervention. Method of measurement: Pain intensity is measured using a visual analogue scale from zero to ten following application of cold spray on a cotton pellet placed on the buccal cervical surface of the tooth for one second.;Pain intensity induced by heat stimulus in teeth with dentin hypersensitivity. Timepoint: At baseline before intervention; ten minutes after initial treatment; two days after treatment ten minutes after gel application; four days after treatment ten minutes after gel application; two weeks after intervention; four weeks after intervention. Method of measurement: Pain intensity is measured using a visual analogue scale from zero to ten following application of heated gutta percha on the buccal surface of the tooth for a maximum of three seconds or until pain is reported.	—

Measure

Time frame

Pain intensity induced by cold stimulus in teeth with dentin hypersensitivity. Timepoint: At baseline before intervention; ten minutes after initial treatment; two days after treatment ten minutes after gel application; four days after treatment ten minutes after gel application; two weeks after intervention; four weeks after intervention. Method of measurement: Pain intensity is measured using a visual analogue scale from zero to ten following application of cold spray on a cotton pellet placed on the buccal cervical surface of the tooth for one second.;Pain intensity induced by heat stimulus in teeth with dentin hypersensitivity. Timepoint: At baseline before intervention; ten minutes after initial treatment; two days after treatment ten minutes after gel application; four days after treatment ten minutes after gel application; two weeks after intervention; four weeks after intervention. Method of measurement: Pain intensity is measured using a visual analogue scale from zero to ten following application of heated gutta percha on the buccal surface of the tooth for a maximum of three seconds or until pain is reported.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyyed Amir Seyyedi

Oroumia University of Medical Sciences

seyyediamir@yahoo.com+98 44 3322 4288

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026