stroke. Stroke, not specified as haemorrhage or infarction
Conditions
Interventions
Intervention 1: Intervention group 1: PRP therapy group will receive one intramuscular injection of autologous platelet-rich plasma (PRP) in their biceps brachii muscle. PRP is extracted from autolog
15 to 50 cc of blood is taken from the patient to prepare PRP, then PRP is prepared and injected. Intervention 2: Intervention group 2: MSCs therapy group will receive one intramuscular injection of
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients suffering from stroke for the first time Patients who have had at least 6 months of stroke Stroke patients in the age range of 40 to 70 years Patients who are able to understand commands Stroke patients with elbow flexor muscle spasticity 1 and above according to MMAS Stroke patients whose upper limb function is in Brunnstrom stage 3
Exclusion criteria
Exclusion criteria: History of previous stroke or other central nervous system disorders that can lead to spasticity Patients who have fixed elbow contracture Patients who have had Botox injections in the elbow flexor muscle in the last year The patient's lack of consent to continue participating in the study Incidence of recurrent stroke during the study period A systemic reaction to the treatment that makes it impossible to continue the investigation Patients who have contraindications for PRP Therapy include: Platelet dysfunction syndrome, Critical thrombocytopenia, Hemodynamic instability, Septicemia, Corticosteroid injection within the last 1 month, Smoking, Fever or cancerous disease, especially of blood-forming cells or bone, Hb< 10 g/dl, Number of platelets less than 105 /µl, Local infection at the injection site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spasticity. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: Modified Modified Ashworh Scale (MMAS).;Motor recovery stage. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: Brunnstrom recovery stages table.;Active and passive Range of Motion (ROM) of elbow. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: A universal goniometer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Fascicle length. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Pennation angle. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Muscle thickness. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography.;Echo intensity. Timepoint: at baseline and 1, 2 and 3 months after intervention. Method of measurement: sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSimin Rajaeian
Tehran University of Medical Sciences
Outcome results
None listed