Infertility related to women with a history of at least two implantation failures (RIF).. Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Pelvic electrotherapy. They receive the usual medical treatment. From the 6th to the 12th day of the cycle, oral amlodipine is prescribed once a day at a dose of 5
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Days
Inclusion criteria
Inclusion criteria: Female Age between 20 and 40 years History of at least two failed transfers Embryo grade A or B
Exclusion criteria
Exclusion criteria: Having any of the cases of congenital anomaly of the uterus, fibroids or any intrauterine lesions, severe endometriosis, uterine myomas, uterine adenomyosis, ovarian cysts and antral follicles with sizes larger than 12 mm, severe ovulation disorder including prolonged oligoamenorrhea, premature ovarian failure and hypothalamic amenorrhea, suffering from any internal disease associated with blood flow disorders such as diabetes and dyslipidemia, smoking and alcohol consumption, special diets such as vegetarianism, autoimmune diseases, hypertension and coagulation disorders, intrauterine adhesions ( Asherman syndrome)and other organic injuries, uterine dysplasia, mental illnesses, mental disorders, contraindications for estrogen therapy, anemia, hyperthyroidism, heart disease, liver disease, kidney disease, and other diseases that lead to a decrease in menstruation People whose embryos are not grade A or B after resuscitation or the thickness of the endometrium is less than 6 mm on the day of endometrial conversion,
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: successful pregnancyoutcomes of the research. Timepoint: Before entering the study,12 weeks after implantation. Method of measurement: To check a successful pregnancy, the implantation rate, the number of gestational sacs and the growth of the fetus until the 12th week of pregnancy will be recorded and analyzed and compared. | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial resistance index. Timepoint: Before entering the study, after drug and electrotherapy intervention (after 1 Month). Method of measurement: Examination of arterial resistance index is done using transvaginal ultrasound. To identify the state of uterine blood supply, the blood flow changes of the uterine arteries, arcuate artery and subendometrial vessels will be investigated in the follicular stage. Measurements will be reported independently for the right and left uterine arteries.;Arterial pulsatility index. Timepoint: Before entering the study, after drug and electrotherapy intervention (after 1 Month). Method of measurement: Examination of arterial pulsatility index is done using transvaginal ultrasound. To identify the state of uterine blood supply, the blood flow changes of the uterine arteries, arcuate artery and subendometrial vessels will be investigated in the follicular stage. Measurements will be reported independently for the right and left uterine arteries.;Peak systolic velocity. Timepoint: Before entering the study, after drug and electrotherapy intervention (after 1 Month). Method of measurement: Examination of peak systolic velocity is done using transvaginal ultrasound. To identify the state of uterine blood supply, the blood flow changes of the uterine arteries, arcuate artery and subendometrial vessels will be investigated in the follicular stage. Measurements will be reported independently for the right and left uterine arteries.;End diastolic velocity. Timepoint: Before entering the study, after drug and electrotherapy intervention (after 1 Month). Method of measurement: Examination of end diastolic velocity is done using transvaginal ultrasound. To identify the state of uterine blood supply, the blood flow changes of the uterine arteries, arcuate artery and subendometrial vessels will be investigated in the follicular stage. Measurements will be reported independently for the right and left uterine arteries.;Endometrial pattern. Timep | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZahra Chakeri
Tabriz University of Medical Sciences
Outcome results
None listed