The effect of simultaneous administration of ketamine-propofol and propofol intravenous infusion on brain relaxation in supratentorial tumor surgery.

Comparison of the effect of simultaneous administration of ketamine-propofol and propofol intravenous infusion on brain relaxation based on brain relaxation score in patients undergoing supratentorial tumors surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230204057318N5

Enrollment

Registered

2024-10-11

Start date

2024-11-01

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

supratentorial brain tumor. Benign neoplasm of brain, supratentorial

Interventions

Intervention 1: Intervention group: PF group, induction of general anesthesia with propofol 2mg/kg, atracurium 0.5mg/kg, lidocaine 1mg/kg. In the PF group, anesthesia will continue with propofol 200mc

Eligibility

Sex/Gender

All

Age

16 Years to No maximum

Inclusion criteria

Inclusion criteria: Mental health and providing informed consent All elective surgeries of supratentorial tumors

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Brain relaxation based on brain relaxation score. Timepoint: Intraoperative. Method of measurement: observation scale 1 to 4.	—

Secondary

Measure	Time frame
Intraoperative opioid consumption. Timepoint: Intraoperative. Method of measurement: Patient file information.;Stroke volume variability. Timepoint: Intraoperative. Method of measurement: Patient file information.;Riker Sedation-Agitation Scale. Timepoint: Recovery room. Method of measurement: Riker score scale.;Postoperative pain. Timepoint: Postoperative up to 24h. Method of measurement: Visual analog scale.	—

Measure

Time frame

Intraoperative opioid consumption. Timepoint: Intraoperative. Method of measurement: Patient file information.;Stroke volume variability. Timepoint: Intraoperative. Method of measurement: Patient file information.;Riker Sedation-Agitation Scale. Timepoint: Recovery room. Method of measurement: Riker score scale.;Postoperative pain. Timepoint: Postoperative up to 24h. Method of measurement: Visual analog scale.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahid Beheshti University of Medical Sciences

Shahid Beheshti University of Medical Sciences

dr.alirezashakeri@gmail.com+98 21 7343 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026