Intraoperative radical cystectomy. Intraoperative hemorrhage and hematoma of a circulatory system organ or structure complicating other procedure
Conditions
Interventions
Intervention 1: Intervention group: After general anesthesia, patients in the fibrinogen group will be administered two grams of fibrinogen intravenously dissolved in 100 ml of distilled water. Interv
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who are candidates for elective radical cystectomy surgery under general anesthesia with muscle relaxation and mechanical ventilation
Exclusion criteria
Exclusion criteria: Patient on anticoagulant agent Having a known blood Abnormality or coagulopathy Chronic liver disease Chronic kidney disease with a serum creatinine level of > 2 mg/dL Preoperative plasma fibrinogen level of =150 or = 400 mg/dL History of heart infarction, deep vein thrombosis, pulmonary embolism, stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemorrhage. Timepoint: Intraoperative. Method of measurement: Measuring of the suction bottle and bloody gauze and hemoglobin level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization days. Timepoint: Postoperative period. Method of measurement: days.;ICU length of stay. Timepoint: Postoperative period. Method of measurement: Days.;Arterial blood gas. Timepoint: Intraoperative. Method of measurement: Arterial blood sampling.;Morbidity (Pneumonia, wound infection, postoperative bleeding, Deep vein thrombosis, pulmonary thromboembolism, Stroke, Myocardial infarction). Timepoint: Postoperative. Method of measurement: Patient file.;Packed red blood cells transfusion amount. Timepoint: perioperative. Method of measurement: Milliliters. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAlireza Shakeri
Shahid Beheshti University of Medical Sciences
Outcome results
None listed