Undenatured collagen type 2 supplementation and knee strengthening exercises in knee osteoarthritis

Synergistic effect of undenatured collagen type 2 supplementation and knee strengthening exercises in knee osteoarthritis

Status

Recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230202057310N11

Enrollment

377

Registered

2024-12-22

Start date

2025-01-05

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteroarthritis. Primary osteoarthritis of other joints

Interventions

Intervention 1: Intervention group: Will receive 40 mg/day of undenatured collagen type II supplementation. Intervention 2: Intervention group: Will be given a standardized knee-strengthening exercise

Eligibility

Sex/Gender

All

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adults aged between 35–65 years. Diagnosed with mild-to-moderate knee osteoarthritis based on: Radiographic confirmation (Kellgren-Lawrence grade :1–3). Experiencing knee pain for at least 3 months Able to perform physical activity and follow an exercise regimen Willing to take undenatured collagen type II supplementation as prescribed Not taking any other osteoarthritis-related medications or willing to maintain a washout period of at least 2 weeks prior to enrollment Provided written informed consent to participate in the study.

Exclusion criteria

Exclusion criteria: 1. Diagnosed with severe knee osteoarthritis (Kellgren-Lawrence grade 4). History of knee surgery or any intra-articular injections (e.g., corticosteroids, hyaluronic acid) in the past 6 months. Currently using immunosuppressive therapy or corticosteroids Pregnancy, breastfeeding, or planning to become pregnant during the study Presence of serious systemic diseases Known allergy or intolerance to collagen supplements or any ingredients in the intervention product Presence of other types of arthritis such as rheumatoid arthritis, gout, or infectious arthritis.

Design outcomes

Primary

Measure	Time frame
Osteophytes. Timepoint: 12 weeks. Method of measurement: Knee Xray.;Pain, stiffness and ADLs. Timepoint: 12 weeks. Method of measurement: NPRS and WOMAC Scale.;Knee ROM. Timepoint: 12 weeks. Method of measurement: Goniometry.	—

Secondary

Measure	Time frame
Knee injury outcome. Timepoint: 12 weeks. Method of measurement: Knee injury outcome score (KOOS).;Quality of life. Timepoint: 12 weeks. Method of measurement: SF-36.	—

Countries

Pakistan

Contacts

Public ContactMaliha Khalid Khan

Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan.

malihatareen1997@gmail.com+92 333 6120602

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026