The effect of aerobic exercise concurrent with propolis supplementation in hemodialysis patients

The effect of eight weeks of aerobic exercise with Propolis supplementation on some inflammatory and immune markers in hemodialysis patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230131057295N1

Enrollment

Registered

2023-02-27

Start date

2023-04-04

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with complete renal failure undergoing hemodialysis. Chronic kidney disease, stage 5

Interventions

Intervention 1: Intervention group: 500 mg of propolis extract daily (two 250 mg propolis capsules, one after lunch and one after dinner) and walking 3 days a week with an exercise program according t

Eligibility

Sex/Gender

All

Age

30 Years to 65 Years

Inclusion criteria

Inclusion criteria: An age range of 30 to 65 years ESRD patients on hemodialysis treatment Perform hemodialysis 3 days a week Willingness to participate in research Absence of any allergy to honey and its derivatives Ability to perform aerobic exercise

Exclusion criteria

Exclusion criteria: BMI above 30 Acute heart attack in the last six months Any allergy to honey and its compounds Taking any medicine outside the routine treatment protocol of hemodialysis patients Smoking, drug addiction or alcohol consumption Having any acute illness or cancer, autoimmune diseases

Design outcomes

Primary

Measure	Time frame
CRP. Timepoint: At the beginning and end of the study. Method of measurement: ELISA.;Albumin. Timepoint: At the beginning and end of the study. Method of measurement: BROMOCRESOL GREEN.;CRP to albumin ratio. Timepoint: At the beginning and end of the study. Method of measurement: It will be obtained by dividing the serum levels of C-reactive protein by albumin.;The ratio of neutrophils to lymphocytes. Timepoint: At the beginning and end of the study. Method of measurement: After measuring neutrophils and lymphocytes with a cell counter, these items will be divided and the ratio will be obtained.;The ratio of lymphocytes to platelets. Timepoint: At the beginning and end of the study. Method of measurement: After measuring lymphocytes and platelets with a cell counter, these items will be divided and the ratio will be obtained.;Total antioxidant capacity. Timepoint: At the beginning and end of the study. Method of measurement: By colorimetric method.	—

Measure

Time frame

CRP. Timepoint: At the beginning and end of the study. Method of measurement: ELISA.;Albumin. Timepoint: At the beginning and end of the study. Method of measurement: BROMOCRESOL GREEN.;CRP to albumin ratio. Timepoint: At the beginning and end of the study. Method of measurement: It will be obtained by dividing the serum levels of C-reactive protein by albumin.;The ratio of neutrophils to lymphocytes. Timepoint: At the beginning and end of the study. Method of measurement: After measuring neutrophils and lymphocytes with a cell counter, these items will be divided and the ratio will be obtained.;The ratio of lymphocytes to platelets. Timepoint: At the beginning and end of the study. Method of measurement: After measuring lymphocytes and platelets with a cell counter, these items will be divided and the ratio will be obtained.;Total antioxidant capacity. Timepoint: At the beginning and end of the study. Method of measurement: By colorimetric method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactIman Rahnama

Binaloud institute of higher education

imanrahnama5190@gmail.com+98 51 3423 0564

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026