Bipolar disorder. Bipolar disorder
Conditions
Interventions
Intervention 1: First intervention group: Intramuscular injection of (A or B) Olanzapine 10 mg, maximum 3 doses in 24 hours, second injection after at least 2 hours from the first injection and third
Sponsors
University of social welfare and rehabilitation sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with Bipolar Disorder diagnosed based on DSM-5 criteria according to clinical interview of psychiatrist. Having an overall score of 14 and above (up to 35) in PANSS including five cases of tension, uncooperativeness, hostility, poor impulse control and excitement. Having a rating of 4 (max 7) in at least one of the above five The psychiatrist concludes that the patient should be treated with Olanzapine IM injection or Haloperidol No physical illness associated with mental retardation or other cognitive disorders and neurological disorders Not having severe cardiovascular diseases or cerberovascular in the past 6 months, any severe, acute or unstable medical conditions or laboratory disorders and uncontrolled underlying disease No NMS history No dependence or abuse of substances, drugs or alcohol acutely or in the past 12 months except nicotine or positive urine screen test Patient or guardian's consent
Exclusion criteria
Exclusion criteria: Patients with a history of allergic reaction or intolerance to Olanzapine or Haloperidol. Patients with psychomotor restlessness who have not been diagnosed with bipolar disorder. Unwillingness of the patient or the patient's family to participate in the study. Pregnant or nursing women Patients who have received antipsychotics depo-injectable drugs during the last 1 month. Patients who have used psychological stimuli within 1 week. Patients who received oral or injectable benzodiazepines within the last 4 hours. Patients who have received oral or rapid muscular antipsychotics in the last 2 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Symptom Scale score. Timepoint: 15 minutes, 1 hour and 24 hours later. Method of measurement: Positive and Negative Symptom Scale.;Modified Simpson-angus scale score. Timepoint: 15 minutes, 1 hour and 24 hours later. Method of measurement: Modified Simpson-angus scale.;Richmond Agitation-Sedation Scale score. Timepoint: 15 minutes, 1 hour and 24 hours later. Method of measurement: Richmond Agitation-Sedation Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Khodaparast
University of social welfare and rehabilitation sciences
Outcome results
None listed