Comparison of Intra-Articular PRP and Orthokin Injections for Pain Reduction and Functional Improvement in Patients With Knee Osteoarthritis

Comparative Evaluation of Platelet-Rich Plasma (PRP) and Autologous Conditioned Serum (ACS) in the Management of Symptomatic Knee Osteoarthritis in Patients Referred to the Pain Clinic of Imam Khomeini Hospital Complex

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230130057273N4

Enrollment

Registered

2026-05-09

Start date

2025-12-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: Intra-articular injection of autologous platelet rich plasma prepared from the patient’s peripheral blood. After collection of approximately 60 milliliters of blood

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Diagnosis of knee osteoarthritis grade II or III based on the Lawrence–Kellgren classification Age between 40 and 75 years Persistent knee pain with a severity of at least 5 out of 10 on the Visual Analog Scale (VAS) Ability to attend all study visits and complete follow-up assessments Provision of written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Knee osteoarthritis secondary to trauma, malignancy, gout, or autoimmune diseases Presence of active infection or coagulation disorders History of knee joint intervention within the past one month Use of hormonal therapy within the last three months Use of NSAIDs within the last 10 days

Design outcomes

Primary

Measure	Time frame
Change in knee pain intensity measured by the visual analogue scale from zero to ten, compared with baseline, at one week, one month, and three months after intra articular injection. Timepoint: Pain intensity assessment at baseline before intervention, and at one week, one month, and three months after intra articular injection. Method of measurement: The Visual Analogue Scale as a 10 centimeter line anchored by no pain and worst possible pain.;Knee functional status based on the score of the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire. Timepoint: Assessment of knee functional status at baseline before intervention, one week, one month, and three months after intra articular injection. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire including pain, joint stiffness, and physical function domains.	—

Measure

Time frame

Change in knee pain intensity measured by the visual analogue scale from zero to ten, compared with baseline, at one week, one month, and three months after intra articular injection. Timepoint: Pain intensity assessment at baseline before intervention, and at one week, one month, and three months after intra articular injection. Method of measurement: The Visual Analogue Scale as a 10 centimeter line anchored by no pain and worst possible pain.;Knee functional status based on the score of the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire. Timepoint: Assessment of knee functional status at baseline before intervention, one week, one month, and three months after intra articular injection. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire including pain, joint stiffness, and physical function domains.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBabak Eslami

Tehran University of Medical Sciences

babak.eslaami@gmail.com+98 21 6658 1501

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026