comparing the Effect of corticosteroids and PRP on anosemia with placebo

comparing the effects of injecting a mixture of corticosteroids and platelet-rich plasma in the olfactory cleft of patients with nasal polyposis on the improvement of anosemia after endoscopic sinus surgery and comparing it with placebo.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230127057244N2

Enrollment

Registered

2024-12-27

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Sinusitis. Chronic pansinusitis

Interventions

Intervention 1: Intervention group:Injection of a mixture of one cc platelet-rich plasma solution obtained from centrifugation of patients' blood samples and in one cc triamcinolone from Iran Hormon

Eligibility

Sex/Gender

All

Age

15 Years to 50 Years

Inclusion criteria

Inclusion criteria: Nasal polyposis , Having different severities of olfactory disorder based on the olfactory recognition test score and duration of anosmia less than 2 years.

Exclusion criteria

Exclusion criteria: Head trauma Prior sinus surgery Somking more than 20 pack:year in last year Systemic disease like parkinsone and alzheimer DRAF3 or 2b

Design outcomes

Primary

Measure	Time frame
Olfactory Outcomes. Timepoint: before intervention and 6 month after. Method of measurement: I_SIT Score.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadReza Firozifar

Tehran University of Medical Sciences

mrfirouzifar@sina.tums.ac.ir+98 21 6670 6106

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026