Comparison of the effect of misoprostol and propranolol with misoprostol alone in induction of labor

Comparison of the effect of misoprostol and propranolol with misoprostol alone in induction of labor in mothers referred to Kowsar Hospital in pregnant mothers

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230125057217N1

Enrollment

240

Registered

2024-07-08

Start date

2024-08-20

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Induction of labor. Failed induction of labor

Interventions

Intervention 1: Intervention group: 50 micrograms of sublingual misoprostol up to two doses and propranolol 20 mg tablets (Obeidi Pharmaceutical Company) are given every 6 hours up to two doses, and i

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Gestational age between 38 and 42 weeks Singleton Cephalic presentation Bishop score less than 5

Exclusion criteria

Exclusion criteria: Uterine contractions History of caesarean section Fetal distress Rupture of membran Macrosomy Systolic blood pressure below 100 mm Hg and pulse below 60 and above 120

Design outcomes

Primary

Measure	Time frame
Duration of labor. Timepoint: End of study. Method of measurement: Based on the time measured from induction of labor to final delivery.;Apgar score. Timepoint: 1 and 5 minutes after birth. Method of measurement: Examination.;The duration of the first phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;The duration of the second phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;The duration of the latent phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;Postpartum bleeding. Timepoint: One hour after delivery. Method of measurement: Estimate the amount of bleeding by the delivery agent to cc.	—

Measure

Time frame

Duration of labor. Timepoint: End of study. Method of measurement: Based on the time measured from induction of labor to final delivery.;Apgar score. Timepoint: 1 and 5 minutes after birth. Method of measurement: Examination.;The duration of the first phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;The duration of the second phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;The duration of the latent phase of labor. Timepoint: After delivery. Method of measurement: Information entered in the patient's delivery record.;Postpartum bleeding. Timepoint: One hour after delivery. Method of measurement: Estimate the amount of bleeding by the delivery agent to cc.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomayeh Honarpisheh

Qazvin University of Medical Sciences

dr.s.honarpisheh@gmail.com+98 28 3324 2451

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026