Diabetic foot ulcers caused by uncontrolled diabetes. Type 2 diabetes mellitus with multiple complications
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive daily 2 capsules for 8 weeks containing 10^9 Cfu of bacteria (Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus acidop
Sponsors
Research assistant of Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with diabetic foot ulcers grade 1 and 2 (based on Wagner-Maggett criteria) 20-60 years old 25 = BMI= 35 Informed consent.
Exclusion criteria
Exclusion criteria: Consumption antioxidant supplements such as vitamin E, vitamin C and omega-3 during the study. Consumption other probiotic, prebiotic or synbiotic supplements Conducted separately from this intervention during the study Regular consumption of other forms of probiotics (including: probiotic dairy products, probiotic yogurt, probiotic milk, buttermilk, kefir, sourdough bread, cheeses such as cream cheese, gouda, cheddar, Sausage, Gruyere and other dairy products, types of vinegar and food items containing them. Becoming pregnant Taking antidepressants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ESR. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;CRP. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay. | — |
Secondary
| Measure | Time frame |
|---|---|
| MDA. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;FBS. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Quicki test. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Wound dimensions (length, width, and depth of the wound). Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;TG. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;TOTAL chol. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;HDL. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;LDL. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSorayia Ebrahimpour Koujan
Tehran University of Medical Sciences
Outcome results
None listed