The effect of vitamin C supplementation on oxidative stress indices and skin repigmentation of patient with vitiligo

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230123057193N1

Enrollment

Registered

2023-04-17

Start date

2023-04-08

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vitiligo. L80- Diseases of the skin and subcutaneous tissue.

Interventions

Intervention 1: Intervention group will receive daily 1 tablets of vitamin C 1000 mg with water for 8 weeks. Vitamin C tablets will be purchased from the Gol-darou Company with C Fix brand. All the pa

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Definitive diagnosis of vitiligo by a dermatologist, without gender restrictions Newly diagnosed vitiligo patient (under one month) or less than 10 phototherapy sessions Adults 20-60 years old

Exclusion criteria

Exclusion criteria: Being pregnant or breastfeeding Underlying diseases, including malignancy, history of kidney stones, other chronic and inflammatory diseases except vitiligo Taking antibiotics, antivirals and antifungals Use of vitamin C supplements and antioxidants in the last 3 months Any history of alcohol and tobacco use

Design outcomes

Primary

Measure	Time frame
Catalase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.	—

Secondary

Measure	Time frame
Regimentation. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: vitiligo area scoring index (VASI) score.;Superoxide dismutase. Timepoint: ?????? ?????? (??? ?? ???? ??????) ? 8 ???? ?? ?? ??????. Method of measurement: ELISA assay.;Total oxidant status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Total antioxidant capacity. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Malondialdehyde. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Glutathione peroxidase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.	—

Measure

Time frame

Regimentation. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: vitiligo area scoring index (VASI) score.;Superoxide dismutase. Timepoint: ?????? ?????? (??? ?? ???? ??????) ? 8 ???? ?? ?? ??????. Method of measurement: ELISA assay.;Total oxidant status. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Total antioxidant capacity. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Malondialdehyde. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.;Glutathione peroxidase. Timepoint: Baseline and 8 weeks after intervention. Method of measurement: ELISA assay.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoraiya Ebrahimpour-koujan

Tehran University of Medical Sciences

nutri.seam1@gmail.com+98 21 5563 0553

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 10, 2026