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The effect of topical insulin on wound healing in diabetic patients

Investigating the effect of local insulin administration on wound healing in diabetic patients who underwent surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230116057136N1
Enrollment
40
Registered
2023-05-30
Start date
2023-05-22
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Laparotomy candidate patients.

Interventions

Intervention 1: Intervention group: Patients in the intervention group underwent subcutaneous wound injection with regular insulin at the rate of 0.2 units per kilogram of body weight diluted with 5 c

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Having diabetes Indication of laparotomy with standard Feinstein incision Receive standard prophylactic antibiotics Declaration of informed consent to participate in the study

Exclusion criteria

Exclusion criteria: having an underlying disease that affects the wound healing process, such as cancer and neoplasm, immunodeficiency, history of chemotherapy and radiotherapy Re-incision in similar site of previous surgery Visceral injury during surgery Simultaneity of another surgery The need for blood transfusion during surgery

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Necrotic fascism. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Formation of granulation tissue. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Wound healing time. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Cellulite. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Bleeding. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Wound surface. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.;Infection and purulent discharge. Timepoint: One week, two weeks, four weeks after cutting. Method of measurement: Physical examination and history.

Secondary

MeasureTime frame
Fasting blood sugar test. Timepoint: Before injection and then at an interval of one hour and 4 hours after injection. Method of measurement: Using a glucometer.;Readmission. Timepoint: Intervals of one week, two weeks, four weeks after cutting. Method of measurement: Patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mino Movahdi

Esfahan University of Medical Sciences

internal@med.mui.ac.ir+98 31 3620 1274

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026