Obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: A calorie restricted diet (with 500 kcal less than energy required) with an empagliflozin (10 mg) and topiramate (25 mg/day in the first week of intervention and if
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Men and women over 18 years of age; with body mass index 30-40 kg/m2 with or without hypertension and/or dislipidemia, or body mass index 27-30 kg/m2 with hypertension and/or dislipidemia; without diabetes or eating disorders; not taking vitamin and mineral supplements; not being pregnant or breastfeeding.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Any type of acute illness during the study; not comply with intervention or diet (less than 80% compliance)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anthropometric indices. Timepoint: Before the intervention and 12 weeks after intervention. Method of measurement: The height will be measured with a stadiometer at a standing position, body weight will be measured using a Beurer scale (Beurer, Germany), The waist circumference is measured with inflexible tape measure. The percentage of body fat mass will be determined by bioelectrical impedance analysis (Quad scan 4000; Bodystat). | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose. Timepoint: Before the intervention and 12 weeks after intervention. Method of measurement: Fasting blood glucose levels will be measured using ELISA method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMajid Valizadeh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed