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Evaluation of the effect of intrauterine injection of ciprofloxacin on chronic endometritis

Evaluation of the effect of intrauterine injection of ciprofloxacin on chronic endometritis in patients recurrent implantation failure

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20230111057108N1
Enrollment
30
Registered
2023-02-12
Start date
2023-02-20
Completion date
Unknown
Last updated
2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometritis - Recurrent implantation failure. Endometriosis of uterus

Interventions

Intervention group: The antibiotic regimen of drsoxycycline every 12 hours for 21 days and metronidazole 500 mg every 12 hours for 14 days will continue. In the next menstrual period, sampling will be

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Informed consent to participate in the study Women with chronic endometritis with embryo transfer failure Confirmation of infection using histology and hysteroscopy At least 3 with unsuccessful embryo transfer without genetic, metabolic or endocrine causes

Exclusion criteria

Exclusion criteria: Hypersensitivity to doxycycline and ciprofloxacin Unwillingness to continue participating in the study

Design outcomes

Primary

MeasureTime frame
Reduction of histological symptoms related to endometritis. Timepoint: Before and one month after receiving the medicine. Method of measurement: Laboratory (mild-moderate-severe).

Secondary

MeasureTime frame
Increase the chance of fertility. Timepoint: After receiving the medicine. Method of measurement: Fertility percentage.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Ahmadi

Shahre-kord University of Medical Sciences

nemati.m@skums.ac.ir+98 38 3222 0016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026