Effect of Nicorandil on contrast-induced nephropathy

Evaluation of efficacy of Nicorandil on incidence of contrast-induced nephropathy in patients with GFR < 60% and undergoing coronary angiography and percutaneous coronary intervention- A randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20230110057096N1

Enrollment

264

Registered

2023-02-10

Start date

2023-02-04

Completion date

Unknown

Last updated

2023-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

contrast-induced nephropathy. Nephropathy induced by other drugs, medicaments and biological substances

Interventions

Intervention 1: Control group: In the control group standardad treatment is used and we do not use placebo. as standard treatment tab NAC 1200 mg/po/BD is given to the patients. we also hydrate the pa

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with GFR<60 ml/min that do not undergo dialysis Patients who are a candidate for non-emergent CAG or non-primary PCI and have 24-hour time for treatment with Nicorandil

Exclusion criteria

Exclusion criteria: Consuming Metformin, ACEI, ARB, Nicorandil, Nitrocontin, Sildenafil and other phosphodiesterase 5 inhibitors in the last 24 hours having urinary tract infection(UTI)

Design outcomes

Primary

Measure	Time frame
Creatinine level. Timepoint: Measuring level of creatinine on the days 0-3-5. Method of measurement: Creatinine measurement will be done with the help of a quantitative detection kit for creatinine in serum, plasma or urine with the photometric method of Pars Azmoun company and with the callimetric method without removing proteins based on the JAFFE method.;BUN level. Timepoint: Measuring level of BUN on the days 0-3-5. Method of measurement: BUN will be measured with the help of Urea UV quantitative detection kit in serum, plasma and urine with the photometric method of Pars Azmoun company and with the enzyme method based on the Urease-GLDH method.;Urinary output. Timepoint: Measuring urinary output on the days 0-3-5. Method of measurement: The amount of urinary output is calculated by measuring the volume of a person's urine.	—

Measure

Time frame

Creatinine level. Timepoint: Measuring level of creatinine on the days 0-3-5. Method of measurement: Creatinine measurement will be done with the help of a quantitative detection kit for creatinine in serum, plasma or urine with the photometric method of Pars Azmoun company and with the callimetric method without removing proteins based on the JAFFE method.;BUN level. Timepoint: Measuring level of BUN on the days 0-3-5. Method of measurement: BUN will be measured with the help of Urea UV quantitative detection kit in serum, plasma and urine with the photometric method of Pars Azmoun company and with the enzyme method based on the Urease-GLDH method.;Urinary output. Timepoint: Measuring urinary output on the days 0-3-5. Method of measurement: The amount of urinary output is calculated by measuring the volume of a person's urine.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactArsalan Salari

Rasht University of Medical Sciences

gums.icrc@gmail.com+98 13 3366 9064

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026